PMID- 20182860
OWN - NLM
STAT- MEDLINE
DCOM- 20100628
LR  - 20220318
IS  - 1432-0428 (Electronic)
IS  - 0012-186X (Linking)
VI  - 53
IP  - 5
DP  - 2010 May
TI  - High prevalence of prediabetes and diabetes in a population exposed to high 
      levels of an organochlorine cocktail.
PG  - 899-906
LID - 10.1007/s00125-010-1683-2 [doi]
AB  - AIMS/HYPOTHESIS: A heavily polluted area of Eastern Slovakia was targeted by the 
      PCBRISK cross-sectional survey to search for possible links between environmental 
      pollution and both prediabetes and diabetes. METHODS: Associations of serum 
      levels of five persistent organic pollutants (POPs), namely polychlorinated 
      biphenyls (PCBs), 2,2'-bis(4-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE), 
      2,2'-bis(4-chlorophenyl)-1,1,1-trichloro-ethane (p,p'-DDT), hexachlorobenzene 
      (HCB) and beta-hexachlorocyclohexane (beta-HCH), with prediabetes and diabetes 
      were investigated in 2,047 adults. Diabetes and prediabetes were diagnosed by 
      fasting plasma glucose in all participants and by OGTT in 1,220 compliant 
      participants. RESULTS: Our population was stratified in terms of individual POPs 
      quintiles and associations between environmental pollution, prediabetes and 
      diabetes were investigated. Prevalence of prediabetes and diabetes increased in a 
      dose-dependent manner, with individuals in upper quintiles of individual POPs 
      showing striking increases in prevalence of prediabetes as shown by OR and 95% CI 
      for PCBs (2.74; 1.92-3.90), DDE (1.86; 1.17-2.95), DDT (2.48; 1.77-3.48), HCB 
      (1.86; 1.7-2.95) and beta-HCH (1.97; 1.28-3.04). Interestingly, unlike PCBs, DDT 
      and DDE, increased levels of HCB and beta-HCH seemed not to be associated with 
      increased prevalence of diabetes. Nevertheless, individuals in the 5th quintile 
      of the variable expressing the cumulative effect of all five POPs (sum of orders) 
      had a more than tripled prevalence of prediabetes and more than six times higher 
      prevalence of diabetes when compared with the 1st referent quintile. 
      CONCLUSIONS/INTERPRETATION: Increasing serum concentrations of individual POPs 
      considerably increased prevalence of prediabetes and diabetes in a dose-dependent 
      manner. Interaction of industrial and agricultural pollutants in increasing 
      prevalence of prediabetes or diabetes is likely.
FAU - Ukropec, J
AU  - Ukropec J
AD  - Diabetes Laboratory, Institute of Experimental Endocrinology (an EU Centre of 
      Excellence) Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovak 
      Republic.
FAU - Radikova, Z
AU  - Radikova Z
FAU - Huckova, M
AU  - Huckova M
FAU - Koska, J
AU  - Koska J
FAU - Kocan, A
AU  - Kocan A
FAU - Sebokova, E
AU  - Sebokova E
FAU - Drobna, B
AU  - Drobna B
FAU - Trnovec, T
AU  - Trnovec T
FAU - Susienkova, K
AU  - Susienkova K
FAU - Labudova, V
AU  - Labudova V
FAU - Gasperikova, D
AU  - Gasperikova D
FAU - Langer, P
AU  - Langer P
FAU - Klimes, I
AU  - Klimes I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100225
PL  - Germany
TA  - Diabetologia
JT  - Diabetologia
JID - 0006777
RN  - 0 (Blood Glucose)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus/blood/*epidemiology
MH  - Dose-Response Relationship, Drug
MH  - Environmental Pollutants/*blood
MH  - Environmental Pollution
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/blood/*epidemiology
MH  - Prevalence
MH  - Slovakia/epidemiology
EDAT- 2010/02/26 06:00
MHDA- 2010/06/29 06:00
CRDT- 2010/02/26 06:00
PHST- 2009/11/04 00:00 [received]
PHST- 2010/01/11 00:00 [accepted]
PHST- 2010/02/26 06:00 [entrez]
PHST- 2010/02/26 06:00 [pubmed]
PHST- 2010/06/29 06:00 [medline]
AID - 10.1007/s00125-010-1683-2 [doi]
PST - ppublish
SO  - Diabetologia. 2010 May;53(5):899-906. doi: 10.1007/s00125-010-1683-2. Epub 2010 
      Feb 25.