PMID- 20184133
OWN - NLM
STAT- MEDLINE
DCOM- 20100405
LR  - 20131121
IS  - 0034-8376 (Print)
IS  - 0034-8376 (Linking)
VI  - 61
IP  - 6
DP  - 2009 Nov-Dec
TI  - [Sex steroids and immunity: the role of estrogens on dendritic cells].
PG  - 521-32
AB  - It is well known that 17beta-estradiol have diverse effects on the development of 
      sexual traits, fertility and survival of neurons. On top of these effects, its 
      participation as an important modulator of several immune functions has been 
      described. For instance, estradiol participation has been invoked in relation to 
      the immune sexual dimorphism, and, on sex associated incidence of several 
      autoimmune diseases. Furthermore, its role during the resistance or 
      susceptibility to many diverse infections (such as viral, bacterial and 
      parasitic) has also been demonstrated. Dendritic cells (DCs) have a central role 
      in the activation of the adaptative immune response, and in the maintenance of 
      tolerance. In the last few years, the study of the effects of 17beta-estradiol on 
      DCs has shown that this hormone regulates their differentiation and function, in 
      vitro as well as in vivo. Depending on the context, 17beta-estradiol is able to 
      exert benefic or deletorious effects. In the present communication, we summarize 
      the described effects of estradiol on DCs, comparing the information obtained 
      from studies in vitro versus the information from in vivo experiments.
FAU - Togno-Peirce, Cristian
AU  - Togno-Peirce C
AD  - Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad 
      Nacional Autonoma de Mexico, Mexico, DF. cristiantogno@yahoo.com
FAU - Morales-Montor, Jorge
AU  - Morales-Montor J
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Esteroides sexuales e inmunidad: el papel del estradiol sobre las celulas 
      dendriticas.
PL  - Mexico
TA  - Rev Invest Clin
JT  - Revista de investigacion clinica; organo del Hospital de Enfermedades de la 
      Nutricion
JID - 9421552
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Estradiol/*immunology
MH  - Humans
MH  - Immunity
EDAT- 2010/02/27 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/02/27 06:00
PHST- 2010/02/27 06:00 [entrez]
PHST- 2010/02/27 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
PST - ppublish
SO  - Rev Invest Clin. 2009 Nov-Dec;61(6):521-32.