PMID- 20184922
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20191210
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 210
IP  - 2
DP  - 2010 Jul 11
TI  - The role of the estrogen receptor alpha in the medial amygdala and ventromedial 
      nucleus of the hypothalamus in social recognition, anxiety and aggression.
PG  - 211-20
LID - 10.1016/j.bbr.2010.02.033 [doi]
AB  - Social recognition manifests itself in decreased investigation of a previously 
      encountered individual. Estrogen receptor alpha (ERalpha) knock out mice show 
      deficient social recognition and anxiety. These data show that the ERalpha is 
      involved in these effects, but they do not say anything about the brain sites 
      important for these effects. In this study, an shRNA encoded within an AAV viral 
      vector directed against the ERalpha receptor gene (or containing luciferase 
      control), was injected bilaterally into the posterodorsal amygdala (MePDA) or the 
      ventromedial nucleus of the hypothalamus (VMN) of female rats. An 81% reduction 
      of ERalpha expression in the MePDA eliminated social recognition. Moreover, this 
      diminution of ERalpha in the MePDA reduced anxiety in the light/dark choice test. 
      In contrast, social recognition was unaffected after ERalpha knockdown in the VMN 
      while aggressiveness against the juvenile was enhanced. In conclusion, social 
      recognition and anxiety in female rats are modulated by the ERalpha in the 
      amygdala. Moreover, aggression against juveniles but not against adults could, at 
      least partly, depend on the ERalpha in the VMN.
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - Spiteri, Thierry
AU  - Spiteri T
AD  - Department of Psychology, University of Tromso, Tromso, Norway.
FAU - Musatov, Sergei
AU  - Musatov S
FAU - Ogawa, Sonoko
AU  - Ogawa S
FAU - Ribeiro, Ana
AU  - Ribeiro A
FAU - Pfaff, Donald W
AU  - Pfaff DW
FAU - Agmo, Anders
AU  - Agmo A
LA  - eng
GR  - HD 05751/HD/NICHD NIH HHS/United States
GR  - MH 38273/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100223
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Age Factors
MH  - Aggression/*physiology
MH  - Amygdala/*metabolism
MH  - Animals
MH  - *Anxiety/genetics/pathology/physiopathology
MH  - Choice Behavior/physiology
MH  - Estrogen Receptor alpha/genetics/*metabolism
MH  - Female
MH  - Genetic Vectors/physiology
MH  - Male
MH  - Neuropsychological Tests
MH  - Ovariectomy
MH  - RNA Interference/physiology
MH  - Rats
MH  - Recognition, Psychology/*physiology
MH  - *Social Behavior
MH  - Transduction, Genetic/methods
MH  - Ventromedial Hypothalamic Nucleus/*metabolism
EDAT- 2010/02/27 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/02/27 06:00
PHST- 2010/01/11 00:00 [received]
PHST- 2010/02/16 00:00 [revised]
PHST- 2010/02/17 00:00 [accepted]
PHST- 2010/02/27 06:00 [entrez]
PHST- 2010/02/27 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - S0166-4328(10)00146-4 [pii]
AID - 10.1016/j.bbr.2010.02.033 [doi]
PST - ppublish
SO  - Behav Brain Res. 2010 Jul 11;210(2):211-20. doi: 10.1016/j.bbr.2010.02.033. Epub 
      2010 Feb 23.