PMID- 20185525
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20220316
IS  - 1532-2114 (Electronic)
IS  - 1532-2114 (Linking)
VI  - 11
IP  - 6
DP  - 2010 Jul
TI  - Strain echocardiography predicts acute coronary occlusion in patients with 
      non-ST-segment elevation acute coronary syndrome.
PG  - 501-8
LID - 10.1093/ejechocard/jeq008 [doi]
AB  - AIMS: Patients with acute coronary occlusion may lack typical signs of myocardial 
      infarction in the electrocardiogram. We tested the ability of different 
      echocardiographic modalities to identify coronary occlusion by quantifying 
      myocardial dysfunction in patients with non-ST-elevation acute coronary syndrome 
      (NSTE-ACS). METHODS AND RESULTS: One hundred and fifty patients were examined by 
      echocardiography immediately prior to coronary angiography, 2.2 +/- 0.7 days 
      (mean +/- SD) after hospitalization for a first NSTE-ACS. Thirty-three patients 
      (22%) had acute coronary occlusion. These patients had impaired left ventricular 
      function as ejection fraction was reduced (54.9 +/- 9.6 vs. 59.1 +/- 7.6%, P = 
      0.02). Regional myocardial function was assessed in a 16-segment model by two 
      methods: longitudinal strain by speckle tracking echocardiography and wall motion 
      score (WMS) by visual assessment. Patients with acute coronary occlusion had an 
      increased number of adjacent dysfunctional segments. The median size of the 
      dysfunctional area by strain was 7 [inter-quartile range (IQR) 4.5-9] vs. 2 (IQR 
      0-5) segments (P < 0.001). An area of >or=4 adjacent dysfunctional segments 
      (strain greater than or equal to -14%) had the best ability to identify patients 
      with acute coronary occlusion, with sensitivity 85% and specificity 70%. WMS 
      demonstrated slightly less accuracy than strain. CONCLUSION: Strain 
      echocardiography identifies NSTE-ACS patients with acute coronary occlusion, who 
      may benefit from urgent reperfusion therapy.
FAU - Eek, Christian
AU  - Eek C
AD  - Department of Cardiology, Rikshospitalet, Oslo University Hospital and University 
      of Oslo, 0027 Oslo, Norway.
FAU - Grenne, Bjornar
AU  - Grenne B
FAU - Brunvand, Harald
AU  - Brunvand H
FAU - Aakhus, Svend
AU  - Aakhus S
FAU - Endresen, Knut
AU  - Endresen K
FAU - Smiseth, Otto A
AU  - Smiseth OA
FAU - Edvardsen, Thor
AU  - Edvardsen T
FAU - Skulstad, Helge
AU  - Skulstad H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100225
PL  - England
TA  - Eur J Echocardiogr
JT  - European journal of echocardiography : the journal of the Working Group on 
      Echocardiography of the European Society of Cardiology
JID - 100890618
RN  - 0 (Biomarkers)
RN  - 0 (Troponin T)
SB  - IM
MH  - Acute Coronary Syndrome/*diagnostic imaging/pathology
MH  - Biomarkers
MH  - Coronary Stenosis/*diagnostic imaging/pathology
MH  - Echocardiography/*instrumentation/methods
MH  - Female
MH  - Health Status Indicators
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnostic imaging/pathology
MH  - ROC Curve
MH  - Risk Assessment
MH  - Statistics as Topic
MH  - Stroke Volume
MH  - Systole
MH  - Troponin T
MH  - Ventricular Function, Left
EDAT- 2010/02/27 06:00
MHDA- 2011/06/22 06:00
CRDT- 2010/02/27 06:00
PHST- 2010/02/27 06:00 [entrez]
PHST- 2010/02/27 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - jeq008 [pii]
AID - 10.1093/ejechocard/jeq008 [doi]
PST - ppublish
SO  - Eur J Echocardiogr. 2010 Jul;11(6):501-8. doi: 10.1093/ejechocard/jeq008. Epub 
      2010 Feb 25.