PMID- 20185624
OWN - NLM
STAT- MEDLINE
DCOM- 20100415
LR  - 20240503
IS  - 1530-8561 (Electronic)
IS  - 0009-9147 (Print)
IS  - 0009-9147 (Linking)
VI  - 56
IP  - 4
DP  - 2010 Apr
TI  - Relation of natriuretic peptides and midregional proadrenomedullin to cardiac 
      chamber volumes by computed tomography in patients without heart failure: from 
      the ROMICAT Trial.
PG  - 651-60
LID - 10.1373/clinchem.2009.138586 [doi]
AB  - BACKGROUND: Stress myocyte biomarkers are used prognostically in patients with 
      cardiovascular disease. We examined associations between amino-terminal 
      pro-B-type natriuretic peptide (NT-proBNP), midregional pro-A-type natriuretic 
      peptide (MR-proANP), and midregional proadrenomedullin (MR-proADM) concentrations 
      and cardiac chamber volumes in chest pain patients without heart failure by use 
      of computed tomography (CT). METHODS: At the time of 64-slice CT scan, we 
      acquired plasma and serum samples for these biomarkers from 346 patients [mean 
      (SD) age 53 (12) years, 65% men]. Left atrial volume (LAV) and left ventricular 
      volumes at end-diastole (LVEDV) and end-systole (LVESV) were measured and indexed 
      to body surface area (LAVI, LVEDI, LVESI). RESULTS: Concentrations of both 
      natriuretic peptides were correlated with LAV and LAVI (r = 0.19-0.32, all P <or= 
      0.0005) and MR-proADM with LV volumes and indices (r = -0.14 to -0.21, all P <or= 
      0.01). NT-proBNP and MR-proANP concentrations were higher in the top quartiles of 
      patients than the lowest quartiles using LAV and LAVI, whereas MR-proADM 
      concentrations were lower in the top quartiles of LV measures. In adjusted 
      analyses, patients had 2- to 4-fold increased risk of LA enlargement for every 
      incremental increase in log(10)NT-proBNP [LAV odds ratio (OR) 2.4, P = 0.03; LAVI 
      OR 4.0, P = 0.003] and 10- to 13-fold increased risk of LA enlargement for every 
      incremental increase in log(10)MR-proANP (LAV OR 10.7, P = 0.009; LAVI OR 13.1, P 
      = 0.004). CONCLUSIONS: In patients without heart failure, both NT-proBNP and 
      MR-proANP concentrations are independently associated with LA enlargement, 
      whereas MR-proADM concentrations are correlated with LV volumes. This may 
      partially explain the well-recognized value of natriuretic peptides for use in 
      risk stratification.
FAU - Truong, Quynh A
AU  - Truong QA
AD  - Cardiac MR PET CT Program, Department of Radiology, Massachusetts General 
      Hospital, Harvard Medical School, Boston, MA 02114, USA. qtruong@partners.org
FAU - Siegel, Emily
AU  - Siegel E
FAU - Karakas, Mahir
AU  - Karakas M
FAU - Januzzi, James L Jr
AU  - Januzzi JL Jr
FAU - Bamberg, Fabian
AU  - Bamberg F
FAU - Mahabadi, Amir A
AU  - Mahabadi AA
FAU - Dasdemir, Selcuk
AU  - Dasdemir S
FAU - Brady, Thomas J
AU  - Brady TJ
FAU - Bergmann, Andreas
AU  - Bergmann A
FAU - Kunde, Jan
AU  - Kunde J
FAU - Nagurney, John T
AU  - Nagurney JT
FAU - Hoffmann, Udo
AU  - Hoffmann U
FAU - Koenig, Wolfgang
AU  - Koenig W
LA  - eng
GR  - T32HL076136/HL/NHLBI NIH HHS/United States
GR  - R01 HL080053/HL/NHLBI NIH HHS/United States
GR  - L30 HL093806-01/HL/NHLBI NIH HHS/United States
GR  - L30 HL093806/HL/NHLBI NIH HHS/United States
GR  - K23 HL098370/HL/NHLBI NIH HHS/United States
GR  - T32 HL076136/HL/NHLBI NIH HHS/United States
GR  - L30HL093896/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100225
PL  - England
TA  - Clin Chem
JT  - Clinical chemistry
JID - 9421549
RN  - 0 (Biomarkers)
RN  - 0 (Protein Precursors)
RN  - 0 (proadrenomedullin)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 148498-78-6 (Adrenomedullin)
SB  - IM
MH  - Adrenomedullin/*blood
MH  - *Atrial Function, Left
MH  - Biomarkers/*blood
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis
MH  - Natriuretic Peptide, Brain/*blood
MH  - Protein Precursors/*blood
MH  - Reproducibility of Results
MH  - Tomography, X-Ray Computed
MH  - *Ventricular Function, Left
PMC - PMC2997388
MID - NIHMS251716
COIS- Authors' Disclosures of Potential Conflicts of Interest: Upon manuscript 
      submission, all authors completed the Disclosures of Potential Conflict of 
      Interest form. Potential conflicts of interest: Employment or Leadership: A. 
      Bergmann, BRAHMS AG; J. Kunde, BRAHMS AG. Consultant or Advisory Role: None 
      declared. Stock Ownership: A. Bergmann, BRAHMS AG (immediate family member). 
      Honoraria: None declared.
EDAT- 2010/02/27 06:00
MHDA- 2010/04/16 06:00
PMCR- 2010/12/05
CRDT- 2010/02/27 06:00
PHST- 2010/02/27 06:00 [entrez]
PHST- 2010/02/27 06:00 [pubmed]
PHST- 2010/04/16 06:00 [medline]
PHST- 2010/12/05 00:00 [pmc-release]
AID - clinchem.2009.138586 [pii]
AID - 10.1373/clinchem.2009.138586 [doi]
PST - ppublish
SO  - Clin Chem. 2010 Apr;56(4):651-60. doi: 10.1373/clinchem.2009.138586. Epub 2010 
      Feb 25.