PMID- 20185943
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20141120
IS  - 1423-0275 (Electronic)
IS  - 0301-1569 (Linking)
VI  - 71 Suppl 1
DP  - 2010
TI  - Hormonal aspects of Meniere's disease on the basis of clinical and experimental 
      studies.
PG  - 1-9
LID - 10.1159/000265113 [doi]
AB  - CONCLUSIONS: Endolymph homeostasis is thought to be mediated by the 
      vasopressin-aquaporin-2 (VP-AQP2) system in the inner ear. Endolymphatic hydrops, 
      the morphological characteristics of Meniere's disease (MD), seems to reflect the 
      malregulation of the VP-AQP2 system in inner ear fluid. The elevation of plasma 
      vasopressin (p-VP) level, which is often observed in MD and its related diseases, 
      might be one of the causative factors underlying these diseases. PURPOSE OF 
      REVIEW: Review of the role of the VP-AQP2 system in the inner ear fluid 
      homeostasis and in the formation and development of endolymphatic hydrops. RECENT 
      CLINICAL AND EXPERIMENTAL FINDINGS: A clinical survey has revealed that the p-VP 
      level is often elevated in MD and its related diseases and that the increase in 
      the p-VP level was closely linked to vertigo attacks in MD. Experimental studies 
      have revealed that proteins and mRNAs of aquaporin-2 and vasopressin type 2 
      receptor were expressed in the stria vascularis of the cochlea and the epithelium 
      of the endolymphatic sac, and that the volume of the endolymphatic compartment 
      was mediated by the activity of the VP-AQP2 system in the inner ear.
FAU - Takeda, Taizo
AU  - Takeda T
AD  - Department of Otolaryngology, Kochi Medical School, Kochi, Japan. 
      takedat@kochi-u.ac.jp
FAU - Takeda, Setsuko
AU  - Takeda S
FAU - Kakigi, Akinobu
AU  - Kakigi A
FAU - Okada, Teruhiko
AU  - Okada T
FAU - Nishioka, Rie
AU  - Nishioka R
FAU - Taguchi, Daizo
AU  - Taguchi D
FAU - Nishimura, Masahiko
AU  - Nishimura M
FAU - Nakatani, Hiroaki
AU  - Nakatani H
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100224
PL  - Switzerland
TA  - ORL J Otorhinolaryngol Relat Spec
JT  - ORL; journal for oto-rhino-laryngology and its related specialties
JID - 0334721
RN  - 0 (Antidiuretic Hormone Receptor Antagonists)
RN  - 0 (Aquaporin 2)
RN  - 0 (Benzazepines)
RN  - 0 (Diuretics)
RN  - 11000-17-2 (Vasopressins)
RN  - 17OJ42922Y (mozavaptan)
RN  - 9FN79X2M3F (Lithium)
SB  - IM
MH  - Animals
MH  - Antidiuretic Hormone Receptor Antagonists
MH  - Aquaporin 2/*metabolism
MH  - Benzazepines/pharmacology
MH  - Diuretics/pharmacology
MH  - Ear, Inner/drug effects/*metabolism/physiopathology
MH  - Endolymph/*metabolism
MH  - Homeostasis
MH  - Humans
MH  - Lithium/pharmacology
MH  - Meniere Disease/drug therapy/*metabolism/physiopathology/psychology
MH  - Vasopressins/*blood
MH  - Water-Electrolyte Imbalance
RF  - 44
EDAT- 2010/03/10 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/02/27 06:00
PHST- 2010/02/27 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - 000265113 [pii]
AID - 10.1159/000265113 [doi]
PST - ppublish
SO  - ORL J Otorhinolaryngol Relat Spec. 2010;71 Suppl 1:1-9. doi: 10.1159/000265113. 
      Epub 2010 Feb 24.