PMID- 20187203
OWN - NLM
STAT- MEDLINE
DCOM- 20100609
LR  - 20191210
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 31
IP  - 3
DP  - 2010 Mar
TI  - Comparison of ferucarbotran-enhanced fluid-attenuated inversion-recovery 
      echo-planar, T2-weighted turbo spin-echo, T2*-weighted gradient-echo, and 
      diffusion-weighted echo-planar imaging for detection of malignant liver lesions.
PG  - 607-16
LID - 10.1002/jmri.22098 [doi]
AB  - PURPOSE: To compare the diagnostic accuracy of superparamagnetic iron oxide 
      (SPIO)-enhanced fluid-attenuated inversion-recovery echo-planar imaging (FLAIR 
      EPI) for malignant liver tumors with that of T2-weighted turbo spin-echo (TSE), 
      T2*-weighted gradient-echo (GRE), and diffusion-weighted echo-planar imaging (DW 
      EPI). MATERIALS AND METHODS: SPIO-enhanced magnetic resonance imaging (MRI) that 
      included FLAIR EPI, T2-weighted TSE, T2*-weighted GRE, and DW EPI sequences was 
      performed using a 3 T system in 54 consecutive patients who underwent surgical 
      exploration with intraoperative ultrasonography. A total of 88 malignant liver 
      tumors were evaluated. Images were reviewed independently by two blinded 
      observers who used a 5-point confidence scale to identify lesions. Results were 
      correlated with results of histopathologic findings and surgical exploration with 
      intraoperative ultrasonography. The accuracy of each MRI sequence was measured 
      with jackknife alternative free-response receiver operating characteristic 
      analysis. The sensitivity of each observer with each MRI sequence was compared 
      with McNemar's test. RESULTS: Accuracy values were significantly higher with 
      FLAIR EPI sequence (0.93) than with T2*-weighted GRE (0.80) or DW EPI sequences 
      (0.80) (P < 0.05). Sensitivity was significantly higher with the FLAIR EPI 
      sequence than with any of the other sequences. CONCLUSION: SPIO-enhanced FLAIR 
      EPI sequence was more accurate in the diagnosis of malignant liver tumors than 
      T2*-weighted GRE and DW EPI sequences. SPIO-enhanced FLAIR EPI sequence is 
      helpful for the detection of malignant liver tumors.
FAU - Fukukura, Yoshihiko
AU  - Fukukura Y
AD  - Department of Radiology, Kagoshima University Graduate School of Medical and 
      Dental Sciences, Kagoshima City, 890-8544, Japan. 
      fukukura@m.kufm.kagoshima-u.ac.jp
FAU - Kamiyama, Takuro
AU  - Kamiyama T
FAU - Takumi, Koji
AU  - Takumi K
FAU - Shindo, Toshikazu
AU  - Shindo T
FAU - Higashi, Ryutaro
AU  - Higashi R
FAU - Nakajo, Masayuki
AU  - Nakajo M
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Contrast Media)
RN  - 0 (Dextrans)
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (Spin Labels)
RN  - G6N3J05W84 (ferumoxides)
RN  - XM0M87F357 (Ferrosoferric Oxide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Contrast Media
MH  - Dextrans
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Echo-Planar Imaging/*methods
MH  - Female
MH  - *Ferrosoferric Oxide
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Information Storage and Retrieval/*methods
MH  - Liver Neoplasms/*diagnosis
MH  - Magnetite Nanoparticles
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Spin Labels
EDAT- 2010/02/27 06:00
MHDA- 2010/06/10 06:00
CRDT- 2010/02/27 06:00
PHST- 2010/02/27 06:00 [entrez]
PHST- 2010/02/27 06:00 [pubmed]
PHST- 2010/06/10 06:00 [medline]
AID - 10.1002/jmri.22098 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2010 Mar;31(3):607-16. doi: 10.1002/jmri.22098.