PMID- 20188426
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20110103
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 146
IP  - 1
DP  - 2011 Jan 7
TI  - High mortality among heart failure patients treated with antidepressants.
PG  - 64-7
LID - 10.1016/j.ijcard.2010.01.006 [doi]
AB  - BACKGROUND: This study was designed to assess whether pharmacologically treated 
      depression was associated with increased mortality risk in systolic heart failure 
      (SHF) patients. METHODS: Patients (n=3346) with SHF (left ventricular ejection 
      fraction </= 0.45) and primarily New York Heart Association (NYHA) classes II-III 
      (78%) were recruited from a clinical database used in 20 heart failure clinics in 
      Denmark. The association between pharmacologically treated depression identified 
      by at least one prescription of an antidepressant and mortality risk was 
      evaluated. RESULTS: Follow-up time was 540 days (range: 30-1600 days). 539 
      patients died. For 243 patients (7%) an antidepressant had been prescribed at 
      least once. In a Cox Proportional Hazard Model, pharmacologically treated 
      depression was associated with a 49% increased mortality risk (Hazard ratio: 
      1.49, 95% confidence interval: 1.03-2.16) after adjustment for traditional 
      confounders. Three months after the baseline visit in the heart failure clinic, 
      these patients received lower doses of beta-blockers than patients without 
      antidepressant therapy (p=0.006). Female sex (p<0.001) and NYHA classes III-IV 
      (p=0.007) were associated with the prescription of an antidepressant. 
      CONCLUSIONS: Our analyses suggest that pharmacologically treated depression is 
      associated with a 49% increased mortality risk, and that these high-risk patients 
      receive lower doses of beta-blockers than patients with no antidepressant 
      therapy.
CI  - Copyright A(c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Veien, Karsten T
AU  - Veien KT
AD  - Department of Cardiology, Odense University Hospital, Sdr. Boulevard 29, DK-5000 
      Odense, Denmark. amtangev@ofir.dk
FAU - Videbaek, Lars
AU  - Videbaek L
FAU - Schou, Morten
AU  - Schou M
FAU - Gustafsson, Finn
AU  - Gustafsson F
FAU - Hald-Steffensen, Flemming
AU  - Hald-Steffensen F
FAU - Hildebrandt, Per R
AU  - Hildebrandt PR
CN  - Danish Heart Failure Clinics Network
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20100226
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Antidepressive Agents)
SB  - IM
CIN - Int J Cardiol. 2011 Jan 7;146(1):94. PMID: 20580445
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antidepressive Agents/*adverse effects
MH  - Depression/complications/*drug therapy/*mortality
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/complications/*drug therapy/*mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Registries
MH  - Risk Factors
MH  - Young Adult
EDAT- 2010/03/02 06:00
MHDA- 2011/11/16 06:00
CRDT- 2010/03/02 06:00
PHST- 2009/08/31 00:00 [received]
PHST- 2010/01/11 00:00 [revised]
PHST- 2010/01/17 00:00 [accepted]
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - S0167-5273(10)00026-4 [pii]
AID - 10.1016/j.ijcard.2010.01.006 [doi]
PST - ppublish
SO  - Int J Cardiol. 2011 Jan 7;146(1):64-7. doi: 10.1016/j.ijcard.2010.01.006. Epub 
      2010 Feb 26.