PMID- 20190481
OWN - NLM
STAT- MEDLINE
DCOM- 20100513
LR  - 20190606
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 49
IP  - 5
DP  - 2010
TI  - Extramedullary relapse of AML with t(9;11)(p22;q23) associated with clonal 
      evolution from trisomy 8 into tetrasomy 8.
PG  - 447-51
AB  - This report describes a patient with extramedullary relapse of acute myeloid 
      leukemia (AML) without involving bone marrow. A 57-year-old man was diagnosed as 
      having acute monoblastic leukemia with t(9;11)(p22;q23) and trisomy 8. Ten months 
      after achieving complete response (CR) with chemotherapy, masses developed in his 
      left forearm and in the back of his thigh, preceded by enigmatic peripheral 
      neurological symptoms. Aspiration from the forearm showed leukemic relapse, and 
      fluorescence in situ hybridization (FISH) revealed that the majority of the cells 
      had 11q23 anomaly and tetrasomy 8. Bone marrow or meningeal relapse was not 
      observed. To our knowledge, this is the first case report of clonal evolution 
      associated with the development of myeloid sarcoma as a relapse in AML.
FAU - Takahashi, Tohru
AU  - Takahashi T
AD  - Department of Hematology and Gastroenterology, Tenshi Hospital, Sapporo. 
      tohrut@cocoa.ocn.ne.jp
FAU - Tsukuda, Hiroyuki
AU  - Tsukuda H
FAU - Kimura, Hirokazu
AU  - Kimura H
FAU - Yoshimoto, Mitsuru
AU  - Yoshimoto M
FAU - Tsujisaki, Masayuki
AU  - Tsujisaki M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100301
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
SB  - IM
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Chromosomes, Human, Pair 9/*genetics
MH  - Drug Therapy
MH  - Forearm
MH  - Humans
MH  - Leukemia, Myeloid, Acute/drug therapy/*genetics
MH  - Male
MH  - Middle Aged
MH  - Recurrence
MH  - Sarcoma, Myeloid/*diagnosis/*genetics
MH  - Thigh
MH  - Trisomy/*genetics
EDAT- 2010/03/02 06:00
MHDA- 2010/05/14 06:00
CRDT- 2010/03/02 06:00
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2010/05/14 06:00 [medline]
AID - JST.JSTAGE/internalmedicine/49.2904 [pii]
AID - 10.2169/internalmedicine.49.2904 [doi]
PST - ppublish
SO  - Intern Med. 2010;49(5):447-51. doi: 10.2169/internalmedicine.49.2904. Epub 2010 
      Mar 1.