PMID- 20190525
OWN - NLM
STAT- MEDLINE
DCOM- 20100429
LR  - 20190724
IS  - 0031-6903 (Print)
IS  - 0031-6903 (Linking)
VI  - 130
IP  - 3
DP  - 2010 Mar
TI  - Crystalline drug aconitine-loaded poly(d,l-lactide-coglycolide) nanoparticles: 
      preparation and in vitro release.
PG  - 409-18
AB  - This paper reports both the optimization of aconitine entrapment and its release 
      from biodegradable poly(d,l-lactide-coglycolide) (PLGA) nanoparticles prepared 
      using the O/W single-emulsion/solvent-evaporation technique. The influence of 
      several parameters, such as the initial aconitine mass, aqueous-phase pH, volume 
      ratio of aqueous/organic phase (W/O), PLGA concentration in the organic phase, 
      etc., on aconitine encapsulation were investigated. The optimized nanoparticles 
      had an entrapment efficiency of 88.40+/-3.02% with drug loading capacity of 
      9.42+/-2.93%. Crystallization growth, which played a crucial role in hindering 
      the incorporation of aconitine into the polymer carrier, was proposed. 
      Differential scanning calorimetry and X-ray powder diffraction demonstrated that 
      aconitine existed in an amorphous state or as a solid solution in the polymeric 
      matrix. The in vitro release profiles exhibited a sustained release of aconitine 
      from nanoparticles and a pH-dependent character in phosphate-buffered saline with 
      different pH values. Moreover, aconitine-loaded PLGA nanoparticles could lead to 
      improvement in the stability of aconitine. This work demonstrated the feasibility 
      of encapsulating aconitine into PLGA nanoparticles using the O/W 
      single-emulsion/solvent-evaporation technique.
FAU - Xu, Xuefan
AU  - Xu X
AD  - Key Laboratory of Drug Targeting of the Ministry of Education, West China School 
      of Pharmacy, Sichuan University, China.
FAU - Xiang, Qingyu
AU  - Xiang Q
FAU - He, Zhiyao
AU  - He Z
FAU - Liu, Yuehua
AU  - Liu Y
FAU - Zhou, Dan
AU  - Zhou D
FAU - Qin, Xuan
AU  - Qin X
FAU - Fan, Tingting
AU  - Fan T
FAU - Zhang, Zhirong
AU  - Zhang Z
FAU - Huang, Yuan
AU  - Huang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Yakugaku Zasshi
JT  - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JID - 0413613
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Nanocapsules)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - X8YN71D5WC (Aconitine)
SB  - IM
MH  - *Aconitine/administration & dosage/pharmacokinetics
MH  - Chemistry, Pharmaceutical
MH  - Crystallization
MH  - Delayed-Action Preparations
MH  - *Drug Delivery Systems
MH  - Drug Stability
MH  - Hydrogen-Ion Concentration
MH  - In Vitro Techniques
MH  - *Lactic Acid
MH  - *Nanocapsules
MH  - *Nanoparticles
MH  - Nanotechnology/methods
MH  - *Polyglycolic Acid
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
EDAT- 2010/03/02 06:00
MHDA- 2010/04/30 06:00
CRDT- 2010/03/02 06:00
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2010/04/30 06:00 [medline]
AID - JST.JSTAGE/yakushi/130.409 [pii]
AID - 10.1248/yakushi.130.409 [doi]
PST - ppublish
SO  - Yakugaku Zasshi. 2010 Mar;130(3):409-18. doi: 10.1248/yakushi.130.409.