PMID- 20193011
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20201215
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Linking)
VI  - 234
IP  - 1
DP  - 2010 Mar
TI  - Origin and development of dendritic cells.
PG  - 45-54
LID - 10.1111/j.0105-2896.2009.00879.x [doi]
AB  - Dendritic cells (DCs) are specialized antigen-presenting cells and essential 
      mediators of immunity and tolerance. This group of cells is heterogeneous in 
      terms of cell-surface markers, anatomic location, and function. Here, we review 
      the development and function of DCs found in lymphoid and non-lymphoid tissues in 
      the steady state. DC and monocyte lineages originate from a common progenitor, 
      the monocyte and dendritic cell progenitor (MDP). The two cell types diverge when 
      MDPs give rise to monocytes and committed DC progenitors (CDPs) in the bone 
      marrow. CDPs give rise to pre-DCs, which migrate from the bone marrow to lymphoid 
      and non-lymphoid tissues to produce the two major subpopulations of lymphoid 
      tissue DCs and non-lymphoid tissue CD103(+) DCs. Within tissues and during 
      development, DC division and homeostasis are regulated by the hormone Flt3L.
FAU - Liu, Kang
AU  - Liu K
AD  - Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 
      10065, USA. liuk@rockefeller.edu
FAU - Nussenzweig, Michel C
AU  - Nussenzweig MC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (Antigens, CD)
RN  - 0 (Integrin alpha Chains)
RN  - 0 (Membrane Proteins)
RN  - 0 (alpha E integrins)
RN  - 0 (flt3 ligand protein)
SB  - IM
MH  - Animals
MH  - Antigens, CD/immunology
MH  - Bone Marrow Cells/immunology
MH  - *Cell Differentiation/immunology
MH  - *Cell Lineage/immunology
MH  - Cell Movement
MH  - Dendritic Cells/*immunology/metabolism
MH  - Hematopoietic Stem Cells/*immunology/metabolism
MH  - Homeostasis
MH  - Humans
MH  - Integrin alpha Chains/immunology
MH  - Lymphoid Tissue/cytology/immunology
MH  - Membrane Proteins/metabolism
RF  - 88
EDAT- 2010/03/03 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - IMR879 [pii]
AID - 10.1111/j.0105-2896.2009.00879.x [doi]
PST - ppublish
SO  - Immunol Rev. 2010 Mar;234(1):45-54. doi: 10.1111/j.0105-2896.2009.00879.x.