PMID- 20193012
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20201215
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Linking)
VI  - 234
IP  - 1
DP  - 2010 Mar
TI  - Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in 
      mice.
PG  - 55-75
LID - 10.1111/j.0105-2896.2009.00885.x [doi]
AB  - Dendritic cells (DCs) have been extensively studied in mice lymphoid organs, but 
      less is known about the origin and the mechanisms that regulate DC development 
      and function in non-lymphoid tissues. Here, we discuss recent evidence 
      establishing the contribution of the DC-restricted lineage to the non-lymphoid 
      tissue DC pool and discuss the mechanisms that control the homeostasis of 
      non-lymphoid tissue DCs. We also review recent results underlining the functional 
      specialization of tissue DCs and discuss the potential implications of these 
      findings in tissue immunity and in the development of novel vaccine strategies.
FAU - Helft, Julie
AU  - Helft J
AD  - Department of Gene and Cell Medicine and Mount Sinai School of Medicine, New 
      York, NY, USA.
FAU - Ginhoux, Florent
AU  - Ginhoux F
FAU - Bogunovic, Milena
AU  - Bogunovic M
FAU - Merad, Miriam
AU  - Merad M
LA  - eng
GR  - AI080884/AI/NIAID NIH HHS/United States
GR  - CA112100/CA/NCI NIH HHS/United States
GR  - HL086899/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Transcription Factors)
RN  - 0 (Vaccines)
SB  - IM
MH  - Animals
MH  - *Cell Differentiation/immunology
MH  - *Cell Lineage/immunology
MH  - Cytokines/immunology
MH  - Dendritic Cells/*immunology/metabolism
MH  - Hematopoietic Stem Cells/*immunology/metabolism
MH  - Homeostasis
MH  - Inflammation Mediators/immunology
MH  - Mice
MH  - Phenotype
MH  - Transcription Factors/metabolism
MH  - Vaccines/immunology
RF  - 177
EDAT- 2010/03/03 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - IMR885 [pii]
AID - 10.1111/j.0105-2896.2009.00885.x [doi]
PST - ppublish
SO  - Immunol Rev. 2010 Mar;234(1):55-75. doi: 10.1111/j.0105-2896.2009.00885.x.