PMID- 20193019
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20210105
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Linking)
VI  - 234
IP  - 1
DP  - 2010 Mar
TI  - Comparative genomics as a tool to reveal functional equivalences between human 
      and mouse dendritic cell subsets.
PG  - 177-98
LID - 10.1111/j.0105-2896.2009.00868.x [doi]
AB  - During evolution, vertebrates have developed an adaptive immune system able to 
      cope with a variety of pathogens. Dendritic cells (DCs) are central to this 
      process. DCs integrate information derived from pathogens or endogenous danger 
      signals and convey them to T lymphocytes. Most of the present knowledge on DCs 
      was generated in mice or by using human DCs differentiated in vitro from 
      monocytes. In both species, several DC subsets have been identified in vivo based 
      on differences in their phenotypes, anatomical locations or functions. In mice, 
      protective immunity against intracellular pathogens or tumors can be induced most 
      efficiently by targeting antigens to the CD8 alpha(+) DCs, a subset of DCs which 
      resides in lymphoid tissues and is especially efficient at cross-presenting 
      exogenous antigens to CD8(+) T lymphocytes. In contrary, harnessing human DC 
      subsets for medical purposes is currently hampered by insufficient knowledge 
      about these cells. To overcome this cognitive gap, we are using comparative 
      genomics as a tool for designing hypotheses and experiments to further 
      characterize DC subset functions and their molecular control, including the 
      investigation of the functional equivalences that might exist between human and 
      mouse DC subsets.
FAU - Crozat, Karine
AU  - Crozat K
AD  - Centre d'Immunologie de Marseille-Luminy, Universite de la Mediterranee, 
      Marseille, France.
FAU - Guiton, Rachel
AU  - Guiton R
FAU - Guilliams, Martin
AU  - Guilliams M
FAU - Henri, Sandrine
AU  - Henri S
FAU - Baranek, Thomas
AU  - Baranek T
FAU - Schwartz-Cornil, Isabelle
AU  - Schwartz-Cornil I
FAU - Malissen, Bernard
AU  - Malissen B
FAU - Dalod, Marc
AU  - Dalod M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (Antigens, CD1)
RN  - 0 (Antigens, Surface)
RN  - 0 (CD11b Antigen)
RN  - 0 (CD1C protein, human)
RN  - 0 (CD8 Antigens)
RN  - 0 (CD8 antigen, alpha chain)
RN  - 0 (Glycoproteins)
SB  - IM
MH  - Animals
MH  - Antigens, CD1
MH  - Antigens, Surface/immunology
MH  - CD11b Antigen/immunology
MH  - CD8 Antigens/immunology
MH  - *Cell Differentiation/genetics/immunology
MH  - *Cell Lineage/genetics/immunology
MH  - Communicable Diseases/immunology
MH  - Dendritic Cells/*immunology
MH  - Gene Expression Profiling
MH  - *Genomics/methods
MH  - Glycoproteins
MH  - Humans
MH  - Mice
MH  - Phenotype
MH  - Species Specificity
RF  - 130
EDAT- 2010/03/03 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - IMR868 [pii]
AID - 10.1111/j.0105-2896.2009.00868.x [doi]
PST - ppublish
SO  - Immunol Rev. 2010 Mar;234(1):177-98. doi: 10.1111/j.0105-2896.2009.00868.x.