PMID- 20193022
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20131121
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Linking)
VI  - 234
IP  - 1
DP  - 2010 Mar
TI  - Langerin-expressing dendritic cells in gut-associated lymphoid tissues.
PG  - 233-46
LID - 10.1111/j.0105-2896.2009.00878.x [doi]
AB  - Dendritic cells (DCs) are key regulators of the immune system. They act as 
      professional antigen-presenting cells and are capable of activating naive T cells 
      and stimulating the growth and differentiation of B cells. According to their 
      molecular expression, DCs can be divided into several subsets with different 
      functions. We focus on DC subsets expressing langerin, a C-type lectin. Langerin 
      expression is predominant in skin DCs, but langerin-expressing DCs also exist in 
      mucosal tissue and can be induced by immunization and sometimes by nutrient 
      deficiency. Topical transcutaneous immunization induces langerin(+)CD8 alpha(-) 
      DCs in mesenteric lymph nodes (MLNs), which mediate the production of 
      antigen-specific immunoglobulin A antibody in the intestine. Yet, in one recent 
      study, langerin(+) DCs were generated in gut-associated lymphoid tissue and 
      contributed to the suppressive intestinal immune environment in the absence of 
      retinoic acid. In this review, we focus on the phenotypic and functional 
      characteristics of langerin(+) DCs in the mucosal tissues, especially MLNs.
FAU - Chang, Sun-Young
AU  - Chang SY
AD  - Mucosal Immunology Section, Laboratory Science Division, International Vaccine 
      Institute, Seoul, Korea.
FAU - Kweon, Mi-Na
AU  - Kweon MN
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Surface)
RN  - 0 (CD207 protein, human)
RN  - 0 (Cd207 protein, mouse)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Mannose-Binding Lectins)
RN  - 1C6V77QF41 (Cholecalciferol)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Animals
MH  - Antibody Formation
MH  - Antigens, CD/*immunology
MH  - Antigens, Surface/*immunology
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Cholecalciferol/immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunoglobulin A/biosynthesis
MH  - Langerhans Cells/immunology
MH  - Lectins, C-Type/*immunology
MH  - Lymph Nodes/cytology/*immunology
MH  - Mannose-Binding Lectins/*immunology
MH  - Mice
MH  - Peyer's Patches/cytology/*immunology
MH  - Phenotype
MH  - Signal Transduction
MH  - Tretinoin/immunology
RF  - 88
EDAT- 2010/03/03 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - IMR878 [pii]
AID - 10.1111/j.0105-2896.2009.00878.x [doi]
PST - ppublish
SO  - Immunol Rev. 2010 Mar;234(1):233-46. doi: 10.1111/j.0105-2896.2009.00878.x.