PMID- 20193213
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20221207
IS  - 0254-6450 (Print)
IS  - 0254-6450 (Linking)
VI  - 30
IP  - 8
DP  - 2009 Aug
TI  - [Association between calpain-10 gene polymorphism and risk of type 2 diabetes 
      mellitus: a meta analysis].
PG  - 850-6
AB  - OBJECTIVE: The purpose of this study was to approach the relation of SNP43, SNP44 
      locus, main haplotypes and haplotype combinations with type 2 diabetes mellitus 
      (T2DM). METHODS: According to the theory and principles of systematic review, 
      data from case-control studies regarding the association between calpain-10 
      (CAPN10) gene and T2DM were derived through electronic search of PubMed and 
      Chinese journals databases. To gain a more precise estimation of the 
      relationship, a stratified Meta-analysis with four subgroups was performed 
      according to the races. Publication bias was also assessed. RESULTS: The 
      association with T2DM in different races was evaluated. In Mongoloid race, 
      SNP43-G allele, G/G genotype and 111/221 haplotype combination showed notable 
      association with T2DM with ORs (95%CI) as 1.368 (1.155 - 1.620), 1.437 (1.186 - 
      1.741) and 2.762 (1.287 - 5.927) respectively. In Caucasoid race, SNP44-C allele, 
      111/111 hapotype combination showed strong relationship with T2DM with ORs 
      (95%CI) as 1.144 (1.023 - 1.278), 1.291(1.050 - 1.586) respectively. In Hybrid 
      race, only one positive finding was obtained which was SNP44-C allele with OR 
      (95%CI) as 1.653 (1.025 - 2.665). CONCLUSION: SNP43-G allele, G/G genotype, 
      111/221 were risk factors to Mongoloid race. And SNP-C allele, 111/111 haplotype 
      combination were risk factors to Caucasoid race, and SNP44-C allele to Hybrid 
      race.
FAU - Zhang, Ru-Yang
AU  - Zhang RY
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing 
      Medical University, Nanjing 210029, China.
FAU - Bai, Jian-Ling
AU  - Bai JL
FAU - Yi, Hong-Gang
AU  - Yi HG
FAU - Zhao, Yang
AU  - Zhao Y
FAU - Lin, Yu-di
AU  - Lin YD
FAU - Zhang, Tie-Mei
AU  - Zhang TM
FAU - Chen, Feng
AU  - Chen F
LA  - chi
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - China
TA  - Zhonghua Liu Xing Bing Xue Za Zhi
JT  - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
JID - 8208604
RN  - EC 3.4.22.- (Calpain)
RN  - EC 3.4.22.- (calpain 10)
SB  - IM
MH  - Asian People/*genetics
MH  - Calpain/*genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/ethnology/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Hybridization, Genetic
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
MH  - Publication Bias
MH  - Risk Factors
MH  - White People/*genetics
EDAT- 2010/03/03 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
PST - ppublish
SO  - Zhonghua Liu Xing Bing Xue Za Zhi. 2009 Aug;30(8):850-6.