PMID- 20193583
OWN - NLM
STAT- MEDLINE
DCOM- 20130320
LR  - 20100302
IS  - 0254-6450 (Print)
IS  - 0254-6450 (Linking)
VI  - 30
IP  - 11
DP  - 2009 Nov
TI  - [Association of hemorrhagic fever with renal syndrome and HLA-DRB allele 
      polymorphisms in Han nationality, Hubei province].
PG  - 1143-6
AB  - OBJECTIVE: To understand the association of human leukocyte antigen (HLA)-DRB 
      polymorphism and patients diagnosed as hemorrhagic fever with renal syndrome 
      (HFRS). METHODS: HLA-DR allele polymorphism was detected by PCR-sequence specific 
      primers (PCR-SSP). Hantavirus (HV) typed as Hantaan virus (HTNV) and Seoul virus 
      (SEOV) in patients were detected by RT-heminested PCR. RESULTS: The gene 
      frequency of DRB1*0401-0411, *1001 and *1101-1105 in HFRS case group were 3.1%, 
      2.2% and 15.7% respectively. Compared with control group, it was significant 
      higher in HFRS case group (RR = 13.87, 9.72 and 2.00 respectively with Chi-square 
      value as 10.006, 6.324 and 6.472 respectively, P < 0.05). When compared with HFRS 
      case group, the gene frequency of DRB1*1501-1502, DRB4 and DRB5 in control group 
      were 11.0%, 19.0% and 16.9% respectively, markedly lower than in patients (RR = 
      0.45, 0.58 and 0.23 respectively. Chi-square values were 6.138, 4.583 and 21.076 
      respectively, P < 0.05). There was no significant difference in other HLA-DR gene 
      frequencies. Mixed infection was found in Hubei, with HTNV slightly more than 
      SEOV. Distinct hantaviruses could coexist in either different or the same 
      geographic or ecological zores in Hubei province. Patients with 
      HLA-DRB1*1101-1105 alleles were 81.8% (27/33) infected by HTNV and only 18.2% 
      infected by SEOV, which had significant difference (P < 0.05). CONCLUSION: 
      DRB1*0401-0411, *1001 and *1101-1105 were possibly associated with increased 
      susceptibility to HV infection. On the other hand there was an inverse 
      correlation among HFRS, DRB1*1501-1502, DRB4 and DRB5.
FAU - Wei, Bai
AU  - Wei B
AD  - Department of Gastroenterology, Zhongnan Hospital, Wuhan University, Wuhan 
      430071, China.
FAU - Zhu, You-qing
AU  - Zhu YQ
FAU - Hou, Wei
AU  - Hou W
FAU - Yang, Zhan-qiu
AU  - Yang ZQ
FAU - Sun, Li
AU  - Sun L
FAU - Luo, Fan
AU  - Luo F
FAU - Tang, Xiao-yan
AU  - Tang XY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Liu Xing Bing Xue Za Zhi
JT  - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
JID - 8208604
RN  - 0 (HLA-DR beta-Chains)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-DR beta-Chains/*genetics
MH  - Hemorrhagic Fever with Renal Syndrome/epidemiology/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
EDAT- 2010/03/03 06:00
MHDA- 2013/03/21 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
PST - ppublish
SO  - Zhonghua Liu Xing Bing Xue Za Zhi. 2009 Nov;30(11):1143-6.