PMID- 20193620
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20181201
IS  - 1673-0860 (Print)
IS  - 1673-0860 (Linking)
VI  - 44
IP  - 12
DP  - 2009 Dec
TI  - [Expression of human beta-defensin-2 in laryngeal squamous cell carcinoma and its 
      correlation with CD1a(+) dendritic cells infiltrating in tumor.].
PG  - 1029-33
AB  - OBJECTIVE: To investigate the expression of human beta-defensin-2 (HBD-2) in 
      laryngeal squamous cell carcinoma (LSCC), and reveal the immune significance of 
      HBD-2 in LSCC. METHODS: The expression of HBD-2 and the infiltration of CD1a(+) 
      dendritic cells were verified by immunohistochemistry strept actividin-biotin 
      complex (SABC) method in thirty-four cases of LSCC's paraffin sections, and the 
      expression of HBD-2 mRNA was detected in eighteen cases of postoperative tumor 
      specimens and five cases of normal paracarcinoma tissue using cDNA probe by in 
      situ hybridization. Based on the type and characteristic of datas, SPSS13.0 
      program package was used for statistical calculation. RESULTS: (1) The difference 
      of expression of HBD-2 was significant among the grades of malignant cell 
      differentiation (F = 6.809, P < 0.05), the expression of HBD-2 in well 
      differentiated group was significantly increased compared with moderately and 
      poorly differentiated group (P < 0.05), there wasn't significant difference with 
      the clinical type, T status and lymphatic metastasis in the expression of HBD-2. 
      (2) The difference of expression of HBD-2 mRNA among different grades of 
      malignant cell differentiation was significant (F = 16.391, P < 0.05), less or no 
      positive signal was observed in poorly differentiated group. (3) The infiltration 
      of CD1a(+) dendritic cells had positive correlation with the expression of HBD-2 
      (r = 0.343, P < 0.05). CONCLUSIONS: The expression of HBD-2 was related to the 
      grade of malignant cell differentiation in LSCC, which was regulated at the level 
      of transcription and translation. HBD-2 might play a role in anti-tumor immunity 
      by chemo-attractiving and activating of immature dendritic cells.
FAU - Ren, Xiao-Yong
AU  - Ren XY
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Second Affiliated 
      Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, China.
FAU - Li, Wen-Yan
AU  - Li WY
FAU - Xu, Min
AU  - Xu M
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of 
      otorhinolaryngology head and neck surgery
JID - 101247574
RN  - 0 (beta-Defensins)
SB  - IM
MH  - Carcinoma, Squamous Cell
MH  - Dendritic Cells
MH  - Humans
MH  - *Laryngeal Neoplasms
MH  - Lymphatic Metastasis
MH  - *beta-Defensins
EDAT- 2010/03/03 06:00
MHDA- 2016/04/24 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Dec;44(12):1029-33.