PMID- 20194746
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20220309
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 107
IP  - 11
DP  - 2010 Mar 16
TI  - In vivo vomeronasal stimulation reveals sensory encoding of conspecific and 
      allospecific cues by the mouse accessory olfactory bulb.
PG  - 5172-7
LID - 10.1073/pnas.0915147107 [doi]
AB  - The rodent vomeronasal system plays a critical role in mediating pheromone-evoked 
      social and sexual behaviors. Recent studies of the anatomical and molecular 
      architecture of the vomeronasal organ (VNO) and of its synaptic target, the 
      accessory olfactory bulb (AOB), have suggested that unique features underlie 
      vomeronasal sensory processing. However, the neuronal representation of 
      pheromonal information leading to specific behavioral and endocrine responses has 
      remained largely unexplored due to the experimental difficulty of precise 
      stimulus delivery to the VNO. To determine the basic rules of information 
      processing in the vomeronasal system, we developed a unique preparation that 
      allows controlled and repeated stimulus delivery to the VNO and combined this 
      approach with multisite recordings of neuronal activity in the AOB. We found that 
      urine, a well-characterized pheromone source in mammals, as well as saliva, 
      activates AOB neurons in a manner that reliably encodes the donor animal's sexual 
      and genetic status. We also identified a significant fraction of AOB neurons that 
      respond robustly and selectively to predator cues, suggesting an expanded role 
      for the vomeronasal system in both conspecific and interspecific recognition. 
      Further analysis reveals that mixed stimuli from distinct sources evoke 
      synergistic responses in AOB neurons, thereby supporting the notion of 
      integrative processing of chemosensory information.
FAU - Ben-Shaul, Y
AU  - Ben-Shaul Y
AD  - Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, 
      Harvard University, Cambridge, MA 02138, USA.
FAU - Katz, L C
AU  - Katz LC
FAU - Mooney, R
AU  - Mooney R
FAU - Dulac, C
AU  - Dulac C
LA  - eng
GR  - Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100301
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (TRPC Cation Channels)
RN  - 0 (Trpc2 protein, mouse)
SB  - IM
MH  - Animals
MH  - *Cues
MH  - Female
MH  - Male
MH  - Mice
MH  - Neurons/physiology
MH  - Odorants
MH  - Olfactory Bulb/*physiology
MH  - Physical Stimulation
MH  - Sensation/*physiology
MH  - Sex Characteristics
MH  - Signal Transduction
MH  - Species Specificity
MH  - TRPC Cation Channels
MH  - Time Factors
MH  - Vomeronasal Organ/*physiology
PMC - PMC2841925
COIS- The authors declare no conflict of interest.
EDAT- 2010/03/03 06:00
MHDA- 2010/04/23 06:00
PMCR- 2010/03/16
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
PHST- 2010/03/16 00:00 [pmc-release]
AID - 0915147107 [pii]
AID - 200915147 [pii]
AID - 10.1073/pnas.0915147107 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5172-7. doi: 
      10.1073/pnas.0915147107. Epub 2010 Mar 1.