PMID- 20195467
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 5
IP  - 2
DP  - 2010 Feb 26
TI  - HLA class I restriction as a possible driving force for Chikungunya evolution.
PG  - e9291
LID - 10.1371/journal.pone.0009291 [doi]
LID - e9291
AB  - After two decades of quiescence, epidemic resurgence of Chikungunya fever (CHIKF) 
      was reported in Africa, several islands in the Indian Ocean, South-East Asia and 
      the Pacific causing unprecedented morbidity with some cases of fatality. Early 
      phylogenetic analyses based on partial sequences of Chikungunya virus (CHIKV) 
      have led to speculation that the virus behind recent epidemics may result in 
      greater pathogenicity. To understand the reasons for these new epidemics, we 
      first performed extensive analyses of existing CHIKV sequences from its 
      introduction in 1952 to 2009. Our results revealed the existence of a continuous 
      genotypic lineage, suggesting selective pressure is active in CHIKV evolution. We 
      further showed that CHIKV is undergoing mild positive selection, and that 
      site-specific mutations may be driven by cell-mediated immune pressure, with 
      occasional changes that resulted in the loss of human leukocyte antigen (HLA) 
      class I-restricting elements. These findings provide a basis to understand 
      Chikungunya virus evolution and reveal the power of post-genomic analyses to 
      understand CHIKV and other viral epidemiology. Such an approach is useful for 
      studying the impact of host immunity on pathogen evolution, and may help identify 
      appropriate antigens suitable for subunit vaccine formulations.
FAU - Tong, Joo Chuan
AU  - Tong JC
AD  - Data Mining Department, Institute for Infocomm Research, Fusionopolis, Singapore, 
      Singapore. jctong@i2r.a-star.edu.sg
FAU - Simarmata, Diane
AU  - Simarmata D
FAU - Lin, Raymond T P
AU  - Lin RT
FAU - Renia, Laurent
AU  - Renia L
FAU - Ng, Lisa F P
AU  - Ng LF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100226
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Epitopes)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Africa/epidemiology
MH  - Alphavirus Infections/epidemiology/virology
MH  - Asia, Southeastern/epidemiology
MH  - Chikungunya virus/classification/genetics/*immunology
MH  - Disease Outbreaks
MH  - Epitopes/genetics/immunology
MH  - *Evolution, Molecular
MH  - Gene Frequency
MH  - Genetic Variation
MH  - Geography
MH  - Histocompatibility Antigens Class I/genetics/*immunology
MH  - Humans
MH  - Indian Ocean/epidemiology
MH  - Mutation
MH  - *Phylogeny
MH  - Selection, Genetic
MH  - Species Specificity
PMC - PMC2829075
COIS- Competing Interests: Authors Lisa F.P. Ng and Laurent Renia are on the PLoS ED 
      Board.
EDAT- 2010/03/03 06:00
MHDA- 2010/10/01 06:00
PMCR- 2010/02/26
CRDT- 2010/03/03 06:00
PHST- 2009/11/29 00:00 [received]
PHST- 2010/02/01 00:00 [accepted]
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
PHST- 2010/02/26 00:00 [pmc-release]
AID - 09-PONE-RA-14741R1 [pii]
AID - 10.1371/journal.pone.0009291 [doi]
PST - epublish
SO  - PLoS One. 2010 Feb 26;5(2):e9291. doi: 10.1371/journal.pone.0009291.