PMID- 20196825 OWN - NLM STAT- MEDLINE DCOM- 20100618 LR - 20221207 IS - 1399-0039 (Electronic) IS - 0001-2815 (Linking) VI - 75 IP - 2 DP - 2010 Feb TI - HLA polymorphism in three indigenous populations of Sabah and Sarawak. PG - 166-9 LID - 10.1111/j.1399-0039.2009.01410.x [doi] AB - One hundred and fifty-eight Kadazan, Iban and Bidayuh individuals registered with the Malaysian Marrow Donor Registry were typed for human leukocyte antigen (HLA)-A, HLA-B and HLA-DR. Six, seven and eight HLA-A alleles as well as 13, 15 and 16 HLA-B alleles were detected in the Kadazan, Bidayuh and Iban, respectively. The most common HLA-A allele in all three groups was HLA-A*24 with a frequency of 0.456, 0.490 and 0.422 in the Kadazan, Bidayuh and Iban, respectively. The most common HLA-B allele detected in the Kadazan was HLA-B*40 with a frequency of 0.333; for the Bidayuh and the Iban it was HLA-B*15 with a frequency of 0.460 and 0.275, respectively. The HLA-DR allele with the highest frequency in the Kadazan was HLA-DR*1502 with a frequency of 0.500. In the Iban and the Bidayuh, HLA-DRB1*1202 was the most common DR allele with frequencies of 0.235 and 0.310, respectively. The two most common haplotypes for the Kadazan are A*34-B*38-DR*1502 and A*24-B*40-DR*0405, whereas for the Bidayuh they are A*24-B*15-DR*1602 and A*24-B*35-DR*1202 and for the Iban they are A*34-*B15-DR*1502 and A*24-B*15-DR*1202. FAU - Dhaliwal, J S AU - Dhaliwal JS AD - Allergy and Immunology Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia. jasbir@imr.gov.my FAU - Shahnaz, M AU - Shahnaz M FAU - Azrena, A AU - Azrena A FAU - Irda, Y A AU - Irda YA FAU - Salawati, M AU - Salawati M FAU - Too, C L AU - Too CL FAU - Lee, Y Y AU - Lee YY LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Tissue Antigens JT - Tissue antigens JID - 0331072 RN - 0 (HLA Antigens) RN - 0 (HLA-A Antigens) RN - 0 (HLA-B Antigens) RN - 0 (HLA-B40 Antigen) RN - 0 (HLA-DR Antigens) RN - 0 (HLA-DRB1 Chains) RN - 0 (HLA-DRB1*12:02 antigen) RN - 0 (Histocompatibility Antigens Class I) RN - 0 (Histocompatibility Antigens Class II) SB - IM MH - Alleles MH - Asian People/*genetics MH - HLA Antigens/genetics MH - HLA-A Antigens/genetics MH - HLA-B Antigens MH - HLA-B40 Antigen MH - HLA-DR Antigens MH - HLA-DRB1 Chains MH - Haplotypes MH - Histocompatibility Antigens Class I/*genetics MH - Histocompatibility Antigens Class II/*genetics MH - Humans MH - Malaysia MH - *Polymorphism, Genetic MH - Population Groups/*genetics EDAT- 2010/03/04 06:00 MHDA- 2010/06/19 06:00 CRDT- 2010/03/04 06:00 PHST- 2010/03/04 06:00 [entrez] PHST- 2010/03/04 06:00 [pubmed] PHST- 2010/06/19 06:00 [medline] AID - TAN1410 [pii] AID - 10.1111/j.1399-0039.2009.01410.x [doi] PST - ppublish SO - Tissue Antigens. 2010 Feb;75(2):166-9. doi: 10.1111/j.1399-0039.2009.01410.x.