PMID- 20196826 OWN - NLM STAT- MEDLINE DCOM- 20100618 LR - 20221207 IS - 1399-0039 (Electronic) IS - 0001-2815 (Linking) VI - 75 IP - 2 DP - 2010 Feb TI - HLA-A, -B, -DRB1 allele frequencies and haplotypic association from DNA typing data of 7096 Korean cord blood units. PG - 170-3 LID - 10.1111/j.1399-0039.2009.01418.x [doi] AB - Human leukocyte antigen (HLA) distribution in 7096 Korean cord blood (CB) units preserved at the public CB bank was analyzed by using the polymerase chain reaction with sequence-specific oligonucleotide probe (PCR-SSOP) method. A total of 14 HLA-A, 33 HLA-B, 13 HLA-DRB1 alleles and 2470 three-locus haplotypes were identified. The results are generally similar to those from the previous Korean studies, but the frequencies of less frequent haplotypes < 0.1% are more relevant and infrequent haplotypes with strong linkage disequilibrium were newly found because of the large sample size. Our results showed some similarities to those of other Asians but also some differences, suggesting a rationale for an Asian network for a hematopoietic stem-cell donor registry. Results from this large-scale analysis will be useful in Korean and Asian registry planning. FAU - Yoon, J H AU - Yoon JH AD - Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea. FAU - Shin, S AU - Shin S FAU - Park, M H AU - Park MH FAU - Song, E Y AU - Song EY FAU - Roh, E Y AU - Roh EY LA - eng PT - Journal Article PL - England TA - Tissue Antigens JT - Tissue antigens JID - 0331072 RN - 0 (HLA Antigens) RN - 0 (HLA-A Antigens) RN - 0 (HLA-B Antigens) RN - 0 (HLA-DR Antigens) RN - 0 (HLA-DRB1 Chains) RN - 0 (Histocompatibility Antigens Class I) RN - 0 (Histocompatibility Antigens Class II) SB - IM MH - Asian People/*genetics MH - Fetal Blood MH - *Gene Frequency MH - HLA Antigens/genetics MH - HLA-A Antigens/genetics MH - HLA-B Antigens/genetics MH - HLA-DR Antigens MH - HLA-DRB1 Chains MH - *Haplotypes MH - Histocompatibility Antigens Class I/*genetics MH - Histocompatibility Antigens Class II/*genetics MH - Histocompatibility Testing MH - Humans MH - Korea MH - Linkage Disequilibrium MH - Polymerase Chain Reaction MH - Registries EDAT- 2010/03/04 06:00 MHDA- 2010/06/19 06:00 CRDT- 2010/03/04 06:00 PHST- 2010/03/04 06:00 [entrez] PHST- 2010/03/04 06:00 [pubmed] PHST- 2010/06/19 06:00 [medline] AID - TAN1418 [pii] AID - 10.1111/j.1399-0039.2009.01418.x [doi] PST - ppublish SO - Tissue Antigens. 2010 Feb;75(2):170-3. doi: 10.1111/j.1399-0039.2009.01418.x.