PMID- 20197678
OWN - NLM
STAT- MEDLINE
DCOM- 20100901
LR  - 20100709
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 152
IP  - 4
DP  - 2010
TI  - Characteristics and prognosis of childhood atopic dermatitis: a multicenter study 
      in Turkey.
PG  - 362-7
LID - 10.1159/000288289 [doi]
AB  - BACKGROUND: Childhood atopic dermatitis (AD) is classically accepted as initial 
      finding of atopic march; however, nonatopic cases do not follow this course. The 
      aim of this study was to determine the characteristics and prognosis of AD in 
      childhood in Turkey. METHODS: The study included 531 children with AD that 
      presented to pediatric allergy departments in 11 different regions of Turkey. Age 
      at diagnosis, total serum and inhalant-specific immunoglobulin E (IgE) levels and 
      allergen skin prick test results were recorded retrospectively. Clinical 
      characteristics like additional allergic diseases at presentation or during 
      follow-up were recorded as well as duration of follow-up. RESULTS: Mean age at 
      diagnosis was 37.8 +/- 36.2 months. Mean IgE level was 318.3 +/- 677.8 IU/ml 
      (median 100 IU/ml). Skin prick tests yielded positive results in 47% of children. 
      At presentation, 31.6% of children reported additional allergic disease, while 
      11.7% developed allergic disease during follow-up. Among all, 46.6% had 
      additional allergic disease at any point. IgE levels were significantly higher in 
      children with additional allergic diseases (p = 0.001). Allergen skin prick test 
      positivity and family history of allergic diseases increased the risk of 
      additional allergic diseases significantly (OR = 3.90, 95% CI = 2.3-6.6 and OR = 
      1.89, 95% CI = 1.3-2.8, respectively). CONCLUSIONS: Allergic sensitization is not 
      present in all cases of AD. Coexistence of additional allergic diseases is not as 
      high as expected but more common in children who have been demonstrated to have 
      atopic sensitization with high IgE levels and allergen skin prick test 
      positivity.
CI  - Copyright 2010 S. Karger AG, Basel.
FAU - Yuksel, Hasan
AU  - Yuksel H
AD  - Department of Pediatric Allergy and Pulmonology, Celal Bayar University Medical 
      Faculty, Manisa, Turkey. hyukselefe@hotmail.com
FAU - Can, Demet
AU  - Can D
FAU - Reisli, Ismail
AU  - Reisli I
FAU - Uzuner, Nevin
AU  - Uzuner N
FAU - Orhan, Fazil
AU  - Orhan F
FAU - Cevit, Omer
AU  - Cevit O
FAU - Tahan, Fulya
AU  - Tahan F
FAU - Canitez, Yakup
AU  - Canitez Y
FAU - Kuyucu, Semanur
AU  - Kuyucu S
FAU - Boz, Aysen Bingol
AU  - Boz AB
FAU - Akcay, Ahmet
AU  - Akcay A
FAU - Yilmaz, Ozge
AU  - Yilmaz O
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20100303
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Atopic/blood/*diagnosis/epidemiology/physiopathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypersensitivity/blood/*diagnosis/epidemiology/physiopathology
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Male
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Skin Tests
MH  - Turkey
EDAT- 2010/03/04 06:00
MHDA- 2010/09/02 06:00
CRDT- 2010/03/04 06:00
PHST- 2009/06/04 00:00 [received]
PHST- 2009/09/22 00:00 [accepted]
PHST- 2010/03/04 06:00 [entrez]
PHST- 2010/03/04 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - 000288289 [pii]
AID - 10.1159/000288289 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2010;152(4):362-7. doi: 10.1159/000288289. Epub 2010 
      Mar 3.