PMID- 20197727
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20221207
IS  - 1598-6535 (Print)
IS  - 1598-6535 (Linking)
VI  - 30
IP  - 1
DP  - 2010 Feb
TI  - Estrogen receptor 1, glutathione S-transferase P1, glutathione S-transferase M1, 
      and glutathione S-transferase T1 genes with dysmenorrhea in Korean female 
      adolescents.
PG  - 76-83
LID - 10.3343/kjlm.2010.30.1.76 [doi]
AB  - BACKGROUND: Dysmenorrhea is the most common gynecologic complaint among 
      adolescent females. We investigated the association between genetic polymorphisms 
      and dysmenorrhea. METHODS: A total of 202 postmenarcheal Korean female 
      adolescents 16-17 yr old participated in this study. Genotyping for glutathione 
      S-transferase mu 1 (GSTM1), glutathione S-transferase theta 1 (GSTT1), 
      glutathione S-transferase pi 1 (GSTP1), and estrogen receptor 1 (ESR1) was 
      performed using PCR-based methods. RESULTS: The PP+Pp genotype of the ESR1 gene 
      was more frequent than pp genotypes in subjects with dysmenorrhea than in 
      subjects without dysmenorrhea (odds ratio=2.440; 95% confidence interval, 
      1.036-5.753; P=0.040) using an unadjusted univariate logistic regression 
      analysis. The relationship between dysmenorrhea and ESR1 gene polymorphisms 
      remained significant after adjustment for premenstrual syndrome, years elapsed 
      after menarche, and family history of dysmenorrhea. No significant difference was 
      observed between subjects with dysmenorrhea and subjects without dysmenorrhea for 
      polymorphisms of GSTM1, GSTT1, and GSTP1 genes. CONCLUSIONS: Our results suggest 
      that ESR1 gene polymorphisms may be associated with dysmenorrhea.
FAU - Woo, Hee-Yeon
AU  - Woo HY
AD  - Department of Laboratory Medicine, Kangbuk Samsung Hospital, Sungkyunkwan 
      University School of Medicine, Seoul, Korea.
FAU - Kim, Kye-Hyun
AU  - Kim KH
FAU - Lim, Se-Won
AU  - Lim SW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - Korean J Lab Med
JT  - The Korean journal of laboratory medicine
JID - 101322822
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
RN  - EC 2.5.1.- (glutathione S-transferase T1)
RN  - EC 2.5.1.18 (Glutathione S-Transferase pi)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - EC 2.5.1.18 (glutathione S-transferase M1)
SB  - IM
MH  - Adolescent
MH  - Asian People/genetics
MH  - Dysmenorrhea/*genetics
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Genotype
MH  - Glutathione S-Transferase pi/*genetics
MH  - Glutathione Transferase/*genetics
MH  - Humans
MH  - Logistic Models
MH  - Odds Ratio
MH  - Polymorphism, Genetic
MH  - Republic of Korea
EDAT- 2010/03/04 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/03/04 06:00
PHST- 2010/03/04 06:00 [entrez]
PHST- 2010/03/04 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 201002076 [pii]
AID - 10.3343/kjlm.2010.30.1.76 [doi]
PST - ppublish
SO  - Korean J Lab Med. 2010 Feb;30(1):76-83. doi: 10.3343/kjlm.2010.30.1.76.