PMID- 20198617
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20210103
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 127
IP  - 5
DP  - 2010 Sep 1
TI  - Immune evasion of microsatellite unstable colorectal cancers.
PG  - 1001-10
LID - 10.1002/ijc.25283 [doi]
AB  - Colorectal cancers (CRC) develop through 2 major pathways of genetic instability. 
      In contrast to the majority of CRCs, which are characterized by chromosomal 
      instability, high-level microsatellite unstable (MSI-H) CRCs arise as a 
      consequence of the loss of DNA mismatch repair (MMR) functions and show 
      accumulation of insertion and deletion mutations particularly in microsatellite 
      sequences. MSI-H occurs in about 15% of CRCs, and virtually all CRCs occurring in 
      the context of the hereditary cancer-predisposing Lynch syndrome. These tumors 
      are characterized by a comparably good prognosis and a low frequency of distant 
      metastases. Because of the expression of a defined set of tumor-specific 
      antigens, MSI-H CRCs elicit a strong local and systemic antitumoral immune 
      response of the host and therefore use different strategies to evade the control 
      of the immune system. In this review, we will summarize novel molecular 
      mechanisms that at the same time drive pathogenesis, immunogenicity and immune 
      evasion during the development and progression of MSI-H CRCs. We will focus on 
      the current knowledge about alterations in human leukocyte antigen (HLA) antigen 
      presentation and discuss how immune evasion-while offering protection against 
      local antitumoral immune responses-paradoxically might interfere with the ability 
      of the tumor to form distant organ metastases.
FAU - Kloor, Matthias
AU  - Kloor M
AD  - Department of Applied Tumor Biology, Institute of Pathology, University of 
      Heidelberg, Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany.
FAU - Michel, Sara
AU  - Michel S
FAU - von Knebel Doeberitz, Magnus
AU  - von Knebel Doeberitz M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
SB  - IM
MH  - Colorectal Neoplasms/*immunology
MH  - Humans
MH  - Microsatellite Repeats/*immunology
MH  - *Tumor Escape
RF  - 96
EDAT- 2010/03/04 06:00
MHDA- 2010/08/14 06:00
CRDT- 2010/03/04 06:00
PHST- 2010/03/04 06:00 [entrez]
PHST- 2010/03/04 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
AID - 10.1002/ijc.25283 [doi]
PST - ppublish
SO  - Int J Cancer. 2010 Sep 1;127(5):1001-10. doi: 10.1002/ijc.25283.