PMID- 20199783
OWN - NLM
STAT- MEDLINE
DCOM- 20101027
LR  - 20220317
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 59
IP  - 10
DP  - 2010 Oct
TI  - Venous blood gas and metabolite response to low-intensity muscle contractions 
      with external limb compression.
PG  - 1510-9
LID - 10.1016/j.metabol.2010.01.016 [doi]
AB  - The effect of low-intensity resistance exercise with external limb compression 
      (100 [EC100] and 160 [EC160] mm Hg) on limb blood flow and venous blood 
      gas-metabolite response was investigated and compared with that of high-intensity 
      resistance exercise (no external compression). Unilateral elbow flexion muscle 
      contractions were performed at 20% (75 repetitions, 4 sets, 30-second rest 
      intervals) and 70% of 1-repetition maximum (1-RM; 3 sets, each set was until 
      failure, 3-minute rest intervals). Precontraction brachial arterial blood flow 
      (Doppler ultrasound) was reduced with EC100 or EC160 (56% and 39% of baseline 
      value, respectively) compared with no external compression (control). At 20% 
      1-RM, brachial arterial blood flow increased after contractions performed with 
      EC160 (190%), but not with the others. Decreases in venous oxygen partial 
      pressure (P(v)O(2)) and venous oxygen saturation (S(v)O(2)) were greater during 
      EC100 and EC160 than control (mean [SE]: P(v)O(2), 28 [3] vs 26 [2] vs 33 [2] mm 
      Hg; S(v)O(2), 41% [5%] vs 34% [4%] vs 52% [5%], respectively). Changes in venous 
      pH (pH(v)), venous carbon dioxide partial pressure (P(v)CO(2)), and venous 
      lactate concentration ([L(-)](v)) were greater with EC160 than EC100 and/or 
      control (pH(v), 7.19 [0.01] vs 7.25 [0.01] vs 7.27 [0.02]; P(v)CO(2), 72 [3] vs 
      64 [2] vs 60 [3] mm Hg; [L(-)](v), 5.4 [0.6] vs 3.7 [0.4] vs 3.0 [0.4] mmol/L, 
      respectively). Seventy percent 1-RM contractions resulted in greater changes in 
      pH(v) (7.14 [0.02]), P(v)CO(2) (91 [5] mm Hg), and [L(-)](v) (7.0 [0.5] mmol/L) 
      than EC100 and EC160, but P(v)O(2) (30 [4] mm Hg) and S(v)O(2) (40% [3%]) were 
      similar. In conclusion, changes in pH(v), P(v)CO(2), and [L(-)](v), but not in 
      P(v)O(2) and S(v)O(2), are sensitive to changes in relative, "internal" intensity 
      of low-intensity muscle contractions caused by reduced blood flow (EC160) or 
      high-intensity muscle contractions. Given the magnitude of the changes in pH(v), 
      P(v)CO(2), and [L(-)](v), it appears plausible that they may be involved in 
      stimulating the observed increase in muscle activation via group III and IV 
      afferents.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Yasuda, Tomohiro
AU  - Yasuda T
AD  - Department of Ischemic Circulatory Physiology, Graduate School of Medicine, The 
      University of Tokyo, Tokyo, Japan. yasuda@h.k.u-tokyo.ac.jp
FAU - Abe, Takashi
AU  - Abe T
FAU - Brechue, William F
AU  - Brechue WF
FAU - Iida, Haruko
AU  - Iida H
FAU - Takano, Haruhito
AU  - Takano H
FAU - Meguro, Kentaro
AU  - Meguro K
FAU - Kurano, Miwa
AU  - Kurano M
FAU - Fujita, Satoshi
AU  - Fujita S
FAU - Nakajima, Toshiaki
AU  - Nakajima T
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100304
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Gases)
SB  - IM
MH  - Adult
MH  - Blood Gas Analysis
MH  - Brachial Artery/chemistry/pathology
MH  - Constriction, Pathologic/blood
MH  - Extremities/*blood supply/*pathology/physiology
MH  - Gases/analysis/*blood/*metabolism
MH  - Humans
MH  - Male
MH  - Metabolome/physiology
MH  - Muscle Contraction/*physiology
MH  - Physical Exertion/physiology
MH  - Pressure
MH  - Regional Blood Flow/physiology
MH  - *Resistance Training
MH  - Veins/chemistry/physiology
MH  - Young Adult
EDAT- 2010/03/05 06:00
MHDA- 2010/10/28 06:00
CRDT- 2010/03/05 06:00
PHST- 2009/09/12 00:00 [received]
PHST- 2010/01/05 00:00 [revised]
PHST- 2010/01/21 00:00 [accepted]
PHST- 2010/03/05 06:00 [entrez]
PHST- 2010/03/05 06:00 [pubmed]
PHST- 2010/10/28 06:00 [medline]
AID - S0026-0495(10)00031-4 [pii]
AID - 10.1016/j.metabol.2010.01.016 [doi]
PST - ppublish
SO  - Metabolism. 2010 Oct;59(10):1510-9. doi: 10.1016/j.metabol.2010.01.016. Epub 2010 
      Mar 4.