PMID- 20200816
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20131121
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 118
IP  - 7
DP  - 2010 Jul
TI  - Acute hyperhomocysteinemia impairs endothelium function in subjects with type 2 
      diabetes mellitus.
PG  - 453-8
LID - 10.1055/s-0030-1248290 [doi]
AB  - The objective of the present study was to examine the effect of acute, 
      methionine-induced hyperhomocysteinemia (HHCY) on endothelial function and 
      indices of arterial stiffness in subjects with type 2 diabetes mellitus (T2DM). A 
      total of 30 subjects with T2DM, free of macrovascular disease were examined in a 
      crossover study. L-methionine (M) (0.1 g/kg) and water (W) load were given in 
      random order with an interval of about 1 week in between. Endothelial function 
      was assessed by flow-mediated vasodilation (FMD). Arterial stiffness was assessed 
      by determination of augmentation index (AI). Measurements were performed in the 
      fasting state, 1, 2 and 3 h after the M or the W load. Total plasma homocysteine 
      (HCY) levels did not change after W administration, while M administration 
      resulted in a significant increase in HCY concentrations at 3 h. FMD throughout 
      the experiment expressed as area under the curve (AUC) was significantly lower 
      after the M than after the W load. Consistent with impairment in endothelial 
      function, the AUC of AI was significantly higher after the M than after the W 
      administration. Acute HHCY impairs endothelial function and increases arterial 
      stiffness in patients with T2DM. This effect is probably mediated by a reduction 
      of nitric oxide bioavailability in endothelium.
CI  - J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart, New York.
FAU - Doupis, J
AU  - Doupis J
AD  - First Department of Propaedeutic Medicine, Athens University Medical School, 
      Athens, Greece.
FAU - Eleftheriadou, I
AU  - Eleftheriadou I
FAU - Kokkinos, A
AU  - Kokkinos A
FAU - Perrea, D
AU  - Perrea D
FAU - Pavlatos, S
AU  - Pavlatos S
FAU - Gonis, A
AU  - Gonis A
FAU - Katsilambros, N
AU  - Katsilambros N
FAU - Tentolouris, N
AU  - Tentolouris N
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100303
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (Blood Glucose)
RN  - 0 (Triglycerides)
RN  - 059QF0KO0R (Water)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - Aged
MH  - Blood Glucose/drug effects
MH  - Blood Pressure/drug effects
MH  - Brachial Artery/drug effects/physiopathology
MH  - Cholesterol/blood
MH  - Diabetes Mellitus, Type 2/complications/*physiopathology
MH  - Endothelium, Vascular/*drug effects/physiopathology
MH  - Female
MH  - Heart Rate/drug effects
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/*chemically induced/complications/physiopathology
MH  - Luteal Phase
MH  - Male
MH  - Methionine/*adverse effects/blood
MH  - Middle Aged
MH  - Triglycerides/blood
MH  - Vasodilation/*drug effects
MH  - Water/administration & dosage
EDAT- 2010/03/05 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/03/05 06:00
PHST- 2010/03/05 06:00 [entrez]
PHST- 2010/03/05 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - 10.1055/s-0030-1248290 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2010 Jul;118(7):453-8. doi: 10.1055/s-0030-1248290. 
      Epub 2010 Mar 3.