PMID- 20201554
OWN - NLM
STAT- MEDLINE
DCOM- 20100831
LR  - 20100407
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 58
IP  - 7
DP  - 2010 Apr 14
TI  - Dietary black raspberry anthocyanins do not alter development of obesity in mice 
      fed an obesogenic high-fat diet.
PG  - 3977-83
LID - 10.1021/jf9030772 [doi]
AB  - Anthocyanins (ACNs) from various foods have been shown to minimize the 
      development of obesity in some animal models. The objective of the current study 
      was to compare the effects of feeding purified black raspberry (BRB) ACNs or the 
      freeze-dried whole BRB on the development of obesity. Male C57BL/6J mice (25 days 
      of age) were assigned at random to treatments (7/treatment; 3/cage). The 
      treatments included (1) control low-fat diet (10% calories from fat) (LF); (2) LF 
      plus BRB juice in place of drinking water; (3) LF diet plus purified BRB ACNs in 
      drinking water (1.25 mg/mL); (4) control high-fat diet (60% calories from fat) 
      (HF60); (5) HF60 diet + BRB juice in place of drinking water; (6) HF60 diet + 
      ACNs in drinking water (1.25 mg/mL); and (7) HF60 + freeze-dried whole BRB powder 
      (21.7 g/kg of diet). Body weight gains in mice fed HF60 diet plus purified BRB 
      ACNs tended to be lower after 56, 63, and 70 days than in mice fed HF60 alone. 
      Body weights were increased at time of sacrifice, but heart, liver, and kidney 
      weights as a percentage of body weight were decreased in mice fed HF60 diet 
      compared to LF fed mice. Weights (g or g/body weight) of epididymal and 
      retroperitoneal fat were increased in the HF60 fed mice compared to LF fed mice. 
      Fasting serum glucose, leptin, and insulin levels as well as homeostasis 
      assessment of insulin resistance (HOMA-IR) were elevated in mice fed the HF60 
      diet relative to LF-fed controls. Serum cholesterol, triglycerides, and monocyte 
      chemoattractant protein-1 (MCP-1) were not altered by diet. Serum levels of 
      resistin were increased in mice fed the HF60 diet compared to mice fed the LF 
      diet. None of the responses measured were altered by whole BRB powder included in 
      the diet relative to the HF60 control diet. Cyanidin containing di- or 
      triglycosides in BRB was ineffective in altering the development of obesity in 
      contrast to cyanidin-monoglycosides, which have been shown to be effective. The 
      sugar moiety on the anthocyanidins may be an important factor in determining the 
      response in the development of obesity.
FAU - Prior, Ronald L
AU  - Prior RL
AD  - USDA-ARS, USA. priorronaldl@uams.edu
FAU - Wilkes, Sam
AU  - Wilkes S
FAU - Rogers, Theo
AU  - Rogers T
FAU - Khanal, Ramesh C
AU  - Khanal RC
FAU - Wu, Xianli
AU  - Wu X
FAU - Hager, Tiffany J
AU  - Hager TJ
FAU - Hager, Aaron
AU  - Hager A
FAU - Howard, Luke
AU  - Howard L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Anthocyanins)
RN  - 0 (Dietary Fats)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Anthocyanins/*administration & dosage
MH  - Dietary Fats/*administration & dosage/adverse effects
MH  - Dietary Supplements/*analysis
MH  - Disease Models, Animal
MH  - Disease Progression
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Obesity/drug therapy/*pathology
MH  - Plant Extracts/*administration & dosage
MH  - Random Allocation
MH  - Rosaceae/*chemistry
EDAT- 2010/03/06 06:00
MHDA- 2010/09/02 06:00
CRDT- 2010/03/06 06:00
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - 10.1021/jf9030772 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2010 Apr 14;58(7):3977-83. doi: 10.1021/jf9030772.