PMID- 20202106
OWN - NLM
STAT- MEDLINE
DCOM- 20100831
LR  - 20161018
IS  - 0891-6640 (Print)
IS  - 0891-6640 (Linking)
VI  - 24
IP  - 3
DP  - 2010 May-Jun
TI  - Prevalence of dilated cardiomyopathy in Doberman Pinschers in various age groups.
PG  - 533-8
LID - 10.1111/j.1939-1676.2010.0479.x [doi]
AB  - BACKGROUND: Dilated cardiomyopathy (DCM) in Doberman Pinschers is an autosomal 
      dominant inherited disease. The prevalence of DCM in Doberman Pinschers of 
      various age groups in Europe is currently unknown, but this information would be 
      important to develop recommendations for screening programs. OBJECTIVES: To 
      evaluate the prevalence of cardiomyopathy in various age groups of Dobermans. 
      ANIMALS: Seven hundred and seventy-five examinations in 412 Doberman Pinschers. 
      METHODS: Dogs were included in a prospective longitudinal cohort study. Each 
      examination included echocardiography and 24-hour ECG (Holter) examination. A 
      cut-off value of >100 ventricular premature contractions (VPCs) per 24 hours on 
      Holter examination or abnormal echocardiography was considered diagnostic for 
      cardiomyopathy. The cumulative prevalence included all dogs with DCM and healthy 
      dogs >7 years of age. RESULTS: DCM prevalence in various age groups was as 
      follows: age group 1 (1 to <2 years) 3.3%, age group 2 (2 to <4 years) 9.9%, age 
      group 3 (4 to <6 years) 12.5%, age group 4 (6 to <8 years) 43.6%, and age group 5 
      (>8 years) 44.1%. The cumulative prevalence of Doberman Pinscher cardiomyopathy 
      was 58.2%. There was an equal sex distribution, but male dogs showed earlier 
      echocardiographic changes than did female dogs, which had significantly more 
      VPCs. CONCLUSIONS AND CLINICAL IMPORTANCE: The prevalence of Doberman 
      cardiomyopathy is very high in Europe. Disease manifestation and progression are 
      different between male and female dogs. Yearly screening for DCM by Holter 
      examination and echocardiography is recommended, starting at 2 years of age.
FAU - Wess, G
AU  - Wess G
AD  - Clinic of Small Animal Medicine, Ludwig Maximilians University, Munich, Germany. 
      gwess@lmu.de
FAU - Schulze, A
AU  - Schulze A
FAU - Butz, V
AU  - Butz V
FAU - Simak, J
AU  - Simak J
FAU - Killich, M
AU  - Killich M
FAU - Keller, L J M
AU  - Keller LJ
FAU - Maeurer, J
AU  - Maeurer J
FAU - Hartmann, K
AU  - Hartmann K
LA  - eng
PT  - Journal Article
DEP - 20100223
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Cardiomyopathy, Dilated/diagnosis/*veterinary
MH  - Cohort Studies
MH  - Dog Diseases/*diagnosis
MH  - Dogs
MH  - Female
MH  - Male
EDAT- 2010/03/06 06:00
MHDA- 2010/09/02 06:00
CRDT- 2010/03/06 06:00
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - JVIM479 [pii]
AID - 10.1111/j.1939-1676.2010.0479.x [doi]
PST - ppublish
SO  - J Vet Intern Med. 2010 May-Jun;24(3):533-8. doi: 10.1111/j.1939-1676.2010.0479.x. 
      Epub 2010 Feb 23.