PMID- 20202240
OWN - NLM
STAT- MEDLINE
DCOM- 20110303
LR  - 20190608
IS  - 1677-6119 (Electronic)
IS  - 1677-5538 (Linking)
VI  - 36
IP  - 1
DP  - 2010 Jan-Feb
TI  - The effect of alpha-blocker treatment on bladder hypoxia inducible factor-1 alpha 
      regulation during lower urinary tract obstruction.
PG  - 86-94
AB  - AIMS: To determine whether alpha1-blocker treatment, in chronic bladder outlet 
      obstruction (BOO), influences bladder tissue ischemia. MATERIALS AND METHODS: 
      This prospective study included 60 patients with BOO, of which 40 were under 
      alpha1-blocker medication and 20 without treatment. Patients underwent 
      transurethral resection of the prostate (TURP) or suprapubic prostatectomy (SPP). 
      Ten patients with non-muscle invasive bladder cancer underwent transurethral 
      resection of the bladder tumor and served as the control group. Tissue specimens 
      were immunohistochemically stained for hypoxia inducible factor-1alpha 
      (HIF-1alpha). RESULTS: Bladder tissue from obstructed subjects showed high 
      immunoreactivity to HIF-1alpha. The specimens from the control group, showed no 
      or weak, mainly cytoplasmic immunoreactivity to HIF-1alpha. Patients under alpha 
      -blocker treatment did not differ in the number of HIF-1alpha positive cells 
      compared to subjects with no treatment (median number 86.8 [20-150] and 88.6 
      [0-175], respectively) (p > 0.05). The lowest bladder pressure at which 
      HIF-1alpha was up regulated, was detected at detrusor pressure Qmax (PdetQmax) = 
      60 cm H2O. CONCLUSIONS: Treatment with alpha-blockers in obstructed patients 
      considered as non-responders, does not result in HIF-1alpha down regulation, thus 
      bladder continues to be under chronic stress.
FAU - Koritsiadis, George
AU  - Koritsiadis G
AD  - Department of Urology, Athens University Medical School, LAIKO Hospital, Athens, 
      Greece.
FAU - Tyritzis, Stavros I
AU  - Tyritzis SI
FAU - Koutalellis, George
AU  - Koutalellis G
FAU - Lazaris, Andreas C
AU  - Lazaris AC
FAU - Stravodimos, Konstantinos
AU  - Stravodimos K
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Int Braz J Urol
JT  - International braz j urol : official journal of the Brazilian Society of Urology
JID - 101158091
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Biomarkers)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
SB  - IM
MH  - Adrenergic alpha-Antagonists/*therapeutic use
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/analysis
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*analysis
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Prostatectomy/methods
MH  - Urinary Bladder Neck Obstruction/*drug therapy/metabolism/pathology
EDAT- 2010/03/06 06:00
MHDA- 2011/03/04 06:00
CRDT- 2010/03/06 06:00
PHST- 2009/08/11 00:00 [accepted]
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2011/03/04 06:00 [medline]
AID - IBJUv36n1a12 [pii]
AID - 10.1590/s1677-55382010000100013 [doi]
PST - ppublish
SO  - Int Braz J Urol. 2010 Jan-Feb;36(1):86-94. doi: 10.1590/s1677-55382010000100013.