PMID- 20202421 OWN - NLM STAT- MEDLINE DCOM- 20100601 LR - 20220409 IS - 1080-6059 (Electronic) IS - 1080-6040 (Print) IS - 1080-6040 (Linking) VI - 16 IP - 3 DP - 2010 Mar TI - Invasive Haemophilus influenzae Disease, Europe, 1996-2006. PG - 455-63 LID - 10.3201/eid1603.090290 [doi] AB - An international collaboration was established in 1996 to monitor the impact of routine Haemophilus influenzae type b (Hib) vaccination on invasive H. influenzae disease; 14 countries routinely serotype all clinical isolates. Of the 10,081 invasive H. influenzae infections reported during 1996-2006, 4,466 (44%, incidence 0.28 infections/100,000 population) were due to noncapsulated H. influenzae (ncHi); 2,836 (28%, 0.15/100,000), to Hib; and 690 (7%, 0.036/100,000), to non-b encapsulated H. influenzae. Invasive ncHi infections occurred in older persons more often than Hib (median age 58 years vs. 5 years, p<0.0001) and were associated with higher case-fatality ratios (12% vs. 4%, p<0.0001), particularly in infants (17% vs. 3%, p<0.0001). Among non-b encapsulated H. influenzae, types f (72%) and e (21%) were responsible for almost all cases; the overall case-fatality rate was 9%. Thus, the incidence of invasive non-type b H. influenzae is now higher than that of Hib and is associated with higher case fatality. FAU - Ladhani, Shamez AU - Ladhani S AD - Health Protection Agency, London, UK. shamez.ladhani@hpa.org.uk FAU - Slack, Mary P E AU - Slack MP FAU - Heath, Paul T AU - Heath PT FAU - von Gottberg, Anne AU - von Gottberg A FAU - Chandra, Manosree AU - Chandra M FAU - Ramsay, Mary E AU - Ramsay ME CN - European Union Invasive Bacterial Infection Surveillance participants LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Emerg Infect Dis JT - Emerging infectious diseases JID - 9508155 RN - 0 (Haemophilus Vaccines) RN - 0 (Vaccines, Conjugate) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Child MH - Child, Preschool MH - Europe/epidemiology MH - Female MH - Haemophilus Infections/*epidemiology/microbiology/prevention & control MH - Haemophilus Vaccines/administration & dosage MH - Haemophilus influenzae/classification/*isolation & purification MH - Haemophilus influenzae type b/*isolation & purification MH - Humans MH - Immunization Programs MH - Incidence MH - Infant MH - Male MH - Middle Aged MH - National Health Programs MH - Population Surveillance/methods MH - Vaccines, Conjugate/administration & dosage MH - Young Adult PMC - PMC3322004 FIR - McIntyre, Peter IR - McIntyre P FIR - Gilbert, Lyn IR - Gilbert L FIR - Hogg, Geoff IR - Hogg G FIR - Strauss, Reinhild IR - Strauss R FIR - Heuberger, Sigrid IR - Heuberger S FIR - Hanquet, Germaine IR - Hanquet G FIR - Crokaert, Francoise IR - Crokaert F FIR - Krizova, Pavla IR - Krizova P FIR - Lebedova, Vera IR - Lebedova V FIR - Christensen, Kare Molbak IR - Christensen KM FIR - Jorgen, Jens IR - Jorgen J FIR - Kutsar, Kuulo IR - Kutsar K FIR - Joks, Unna IR - Joks U FIR - Herva, Elja IR - Herva E FIR - Kaijalainen, Tarja IR - Kaijalainen T FIR - Leinonen, Maija IR - Leinonen M FIR - Ruutu, Petri IR - Ruutu P FIR - Lepoutre, Agnes IR - Lepoutre A FIR - Dabernat, Henri IR - Dabernat H FIR - Siedler, Anette IR - Siedler A FIR - Schmitt, Heinz-J IR - Schmitt HJ FIR - Theodoridou, Marie IR - Theodoridou M FIR - Pangalis, Anastasia IR - Pangalis A FIR - Tzanakaki, Georgina IR - Tzanakaki G FIR - Fuzi, Miklos IR - Fuzi M FIR - Krisztalovics, Katalin IR - Krisztalovics K FIR - Gudnason, Thorolfur IR - Gudnason T FIR - Hardardottir, Hjordis IR - Hardardottir H FIR - Cafferkey, Mary IR - Cafferkey M FIR - Cotter, Suzanne IR - Cotter S FIR - O'Flanagan, Darina IR - O'Flanagan D FIR - Dagan, Ron IR - Dagan R FIR - Cerquetti, Marina IR - Cerquetti M FIR - Ciofi, Marta IR - Ciofi M FIR - Lucenko, Irina IR - Lucenko I FIR - Rimseliene, Grazina IR - Rimseliene G FIR - Dauksiene, Snieguole IR - Dauksiene S FIR - Huberty-Krau, Pierette IR - Huberty-Krau P FIR - Schneider, Francois IR - Schneider F FIR - Melillo, Jackie Maistre IR - Melillo JM FIR - de Greeff, Sabine IR - de Greeff S FIR - de Melker, Hester IR - de Melker H FIR - Spanjaard, Lodewijk IR - Spanjaard L FIR - Blystad, Hans IR - Blystad H FIR - Hoiby, E Arne IR - Hoiby EA FIR - Lovoll, Oistein IR - Lovoll O FIR - Zielinski, Andrzej IR - Zielinski A FIR - Hryniewicz, Waleria IR - Hryniewicz W FIR - Skoczynska, Anna IR - Skoczynska A FIR - Kadlubowski, Marcin IR - Kadlubowski M FIR - Queiros, Laurinda IR - Queiros L FIR - Lavado, Paula IR - Lavado P FIR - Cameron, Claire IR - Cameron C FIR - Denham, Barbara IR - Denham B FIR - Johnston, Fiona IR - Johnston F FIR - Slacikova, Margareta IR - Slacikova M FIR - Novakova, Elena IR - Novakova E FIR - Kraigher, Alenka IR - Kraigher A FIR - Paragi, Metka IR - Paragi M FIR - Campos, Jose IR - Campos J FIR - Diez-Domingo, Javier IR - Diez-Domingo J FIR - Carlsson, Rose-Marie IR - Carlsson RM FIR - Normark, Birgitta Henriques IR - Normark BH FIR - Zimmermann, Hans-Peter IR - Zimmermann HP EDAT- 2010/03/06 06:00 MHDA- 2010/06/02 06:00 PMCR- 2010/03/01 CRDT- 2010/03/06 06:00 PHST- 2010/03/06 06:00 [entrez] PHST- 2010/03/06 06:00 [pubmed] PHST- 2010/06/02 06:00 [medline] PHST- 2010/03/01 00:00 [pmc-release] AID - 09-0290 [pii] AID - 10.3201/eid1603.090290 [doi] PST - ppublish SO - Emerg Infect Dis. 2010 Mar;16(3):455-63. doi: 10.3201/eid1603.090290.