PMID- 20202475
OWN - NLM
STAT- MEDLINE
DCOM- 20100730
LR  - 20100511
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 34
IP  - 4
DP  - 2010 May 30
TI  - Higher serum tropomyosin-related kinase B protein level in major depression.
PG  - 610-2
LID - 10.1016/j.pnpbp.2010.02.021 [doi]
AB  - Accumulating evidence suggests that the brain-derived neurotrophic factor (BDNF) 
      and its receptor tropomyosin-related kinase B (TrkB) are molecules involved in 
      the pathophysiology of major depressive disorder and response of antidepressants. 
      To examine both BDNF and TrkB protein levels and their relationship with 
      psychopathology in patients with major depressive disorder, 55 physically healthy 
      patients with major depressive disorder were compared with 53 healthy controls. 
      The severity of major depression was assessed by the 17-item Hamilton Depression 
      Rating Scale (HDRS). Serum BDNF and TrkB protein levels were measured with 
      Enzyme-linked immunosorbent assay (ELISA) kits. After using the analysis of 
      covariance (ANCOVA) with age adjustment, the results of this work showed that 
      BDNF presented no significant difference (F((1,107))=0.149, p=0.701) but the TrkB 
      protein level was significantly higher in depressive patients than in healthy 
      controls (F((1,107))=4.043, p=0.047). These findings suggest that the serum TrkB 
      protein level may play an important role in the psychopathology of major 
      depression.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Hung, Yi-Yung
AU  - Hung YY
AD  - Department of Psychiatry, Chang Gung Memorial Hospital-Kaohsiung Medical Center, 
      Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC.
FAU - Lin, Chia-Ju
AU  - Lin CJ
FAU - Huang, Tiao-Lai
AU  - Huang TL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100302
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Depressive Disorder, Major/*blood/diagnosis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Receptor, trkB/*blood
MH  - Severity of Illness Index
EDAT- 2010/03/06 06:00
MHDA- 2010/07/31 06:00
CRDT- 2010/03/06 06:00
PHST- 2009/11/27 00:00 [received]
PHST- 2010/02/20 00:00 [revised]
PHST- 2010/02/20 00:00 [accepted]
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2010/07/31 06:00 [medline]
AID - S0278-5846(10)00068-0 [pii]
AID - 10.1016/j.pnpbp.2010.02.021 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2010 May 30;34(4):610-2. doi: 
      10.1016/j.pnpbp.2010.02.021. Epub 2010 Mar 2.