PMID- 20203420
OWN - NLM
STAT- MEDLINE
DCOM- 20100622
LR  - 20191111
IS  - 1880-313X (Electronic)
IS  - 0388-6107 (Linking)
VI  - 31
IP  - 1
DP  - 2010 Feb
TI  - Transformation of breast milk macrophages by HTLV-I: implications for HTLV-I 
      transmission via breastfeeding.
PG  - 53-61
AB  - Human T cell leukemia virus type I (HTLV-I), a causative agent of adult T-cell 
      leukemia (ATL), is transmitted from mother to child predominantly by 
      breastfeeding. The source of HTLV-I-infected cells in breast milk has been 
      thought to be T cells, however, the majority of cells in breast milk are CD14(+) 
      macrophages but not CD3(+) T lymphocytes, and no data are available regarding 
      HTLV-I transmission through breast milk macrophages (BrMMpsi). To explore the 
      potential of BrMMpsi as a possible source of infection in mother to child 
      transmission (MTCT) of HTLV-I, an immortalized cell line (HTLV-BrMMpsi) has been 
      established from BrMMpsi by infection with HTLV-I. HTLV-BrMMpsi retained 
      macrophage characteristics and did not express a complete dendritic cell (DC) 
      phenotype; nevertheless, HTLV-BrMMpsi efficiently promoted T cell proliferation 
      in primary allogeneic mixed lymphocyte reaction (MLR) like DC. Moreover, HTLV-I 
      infection could be transmitted from HTLV-BrMMpsi to activated T cells in the 
      peripheral blood. These findings suggested that BrMMpsi might be an appropriate 
      HTLV-I reservoir involved in MTCT transmission via breastfeeding.
FAU - Takeuchi, Hodaka
AU  - Takeuchi H
AD  - Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan.
FAU - Takahashi, Megumi
AU  - Takahashi M
FAU - Norose, Yoshihiko
AU  - Norose Y
FAU - Takeshita, Toshiyuki
AU  - Takeshita T
FAU - Fukunaga, Yoshitaka
AU  - Fukunaga Y
FAU - Takahashi, Hidemi
AU  - Takahashi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biomed Res
JT  - Biomedical research (Tokyo, Japan)
JID - 8100317
SB  - IM
MH  - Adult
MH  - *Breast Feeding
MH  - Cell Line, Transformed
MH  - Cell Proliferation
MH  - *Cell Transformation, Viral
MH  - Coculture Techniques
MH  - Colostrum/*virology
MH  - Female
MH  - HTLV-I Infections/*transmission
MH  - *Human T-lymphotropic virus 1
MH  - Humans
MH  - Infant, Newborn
MH  - Leukemia-Lymphoma, Adult T-Cell/metabolism/*virology
MH  - Macrophages/metabolism/*virology
MH  - Milk, Human/*virology
MH  - Pregnancy
MH  - T-Lymphocytes/metabolism
EDAT- 2010/03/06 06:00
MHDA- 2010/06/23 06:00
CRDT- 2010/03/06 06:00
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2010/06/23 06:00 [medline]
AID - JST.JSTAGE/biomedres/31.53 [pii]
AID - 10.2220/biomedres.31.53 [doi]
PST - ppublish
SO  - Biomed Res. 2010 Feb;31(1):53-61. doi: 10.2220/biomedres.31.53.