PMID- 20205227
OWN - NLM
STAT- MEDLINE
DCOM- 20100331
LR  - 20140730
IS  - 1365-2168 (Electronic)
IS  - 0007-1323 (Linking)
VI  - 97
IP  - 4
DP  - 2010 Apr
TI  - Randomized controlled trial of preoperative oral carbohydrate treatment in major 
      abdominal surgery.
PG  - 485-94
LID - 10.1002/bjs.7026 [doi]
AB  - BACKGROUND: Major surgery is associated with postoperative insulin resistance 
      which is attenuated by preoperative carbohydrate (CHO) treatment. The effect of 
      this treatment on clinical outcome after major abdominal surgery has not been 
      assessed in a double-blind randomized trial. METHODS: Patients undergoing 
      elective colorectal surgery or liver resection were randomized to oral CHO or 
      placebo drinks to be taken on the evening before surgery and 2 h before induction 
      of anaesthesia. Primary outcomes were postoperative length of hospital stay and 
      fatigue measured by visual analogue scale. RESULTS: Sixty-nine and 73 patients 
      were evaluated in the CHO and placebo groups respectively. The groups were well 
      matched with respect to surgical procedure, epidural analgesia, laparoscopic 
      procedures, fasting period before induction and duration of surgery. 
      Postoperative changes in fatigue score from baseline did not differ between the 
      groups. Median (range) hospital stay was 7 (2-35) days in the CHO group and 8 
      (2-92) days in the placebo group (P = 0.344). For patients not receiving epidural 
      blockade or laparoscopic surgery (20 CHO, 19 placebo), values were 7 (3-11) and 9 
      (2-48) days respectively (P = 0.054). CONCLUSION: Preoperative CHO treatment did 
      not improve postoperative fatigue or length of hospital stay after major 
      abdominal surgery. A benefit is not ruled out when epidural blockade or 
      laparoscopic procedures are not used. REGISTRATION NUMBER: ACTRN012605000456651 
      (http://www.anzctr.org.au).
CI  - Copyright (c) 2010 British Journal of Surgery Society Ltd. Published by John 
      Wiley & Sons, Ltd.
FAU - Mathur, S
AU  - Mathur S
AD  - Department of Surgery, University of Auckland, Auckland, New Zealand.
FAU - Plank, L D
AU  - Plank LD
FAU - McCall, J L
AU  - McCall JL
FAU - Shapkov, P
AU  - Shapkov P
FAU - McIlroy, K
AU  - McIlroy K
FAU - Gillanders, L K
AU  - Gillanders LK
FAU - Merrie, A E H
AU  - Merrie AE
FAU - Torrie, J J
AU  - Torrie JJ
FAU - Pugh, F
AU  - Pugh F
FAU - Koea, J B
AU  - Koea JB
FAU - Bissett, I P
AU  - Bissett IP
FAU - Parry, B R
AU  - Parry BR
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Surg
JT  - The British journal of surgery
JID - 0372553
RN  - 0 (Blood Glucose)
RN  - 0 (Carbohydrates)
RN  - 0 (Insulin)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
CIN - Br J Surg. 2010 Apr;97(4):494-5. PMID: 20205225
MH  - Administration, Oral
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Glucose/metabolism
MH  - C-Reactive Protein/metabolism
MH  - Carbohydrates/*administration & dosage
MH  - Colonic Diseases/metabolism/*surgery
MH  - Double-Blind Method
MH  - Fatigue/etiology
MH  - Female
MH  - Hand Strength/physiology
MH  - Humans
MH  - Hydrocortisone/metabolism
MH  - Insulin/metabolism
MH  - Insulin Resistance/physiology
MH  - Laparoscopy
MH  - Length of Stay
MH  - Liver Diseases/metabolism/*surgery
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/anatomy & histology
MH  - Postoperative Complications/metabolism/prevention & control
MH  - Preoperative Care/methods
MH  - Rectal Diseases/metabolism/*surgery
MH  - Treatment Outcome
EDAT- 2010/03/06 06:00
MHDA- 2010/04/01 06:00
CRDT- 2010/03/06 06:00
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2010/04/01 06:00 [medline]
AID - 10.1002/bjs.7026 [doi]
PST - ppublish
SO  - Br J Surg. 2010 Apr;97(4):485-94. doi: 10.1002/bjs.7026.