PMID- 20206377
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20131121
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 408
IP  - 11
DP  - 2010 May 1
TI  - Impact of chronic fluorosis on left ventricular diastolic and global functions.
PG  - 2295-8
LID - 10.1016/j.scitotenv.2010.02.011 [doi]
AB  - Sixty three patients with endemic fluorosis (36 males/27 females; mean age 
      33.9+/-8.6years) and 45 age, sex and body mass index (BMI) matched healthy 
      controls (30 males/15 females; mean age 32.7+/-8.8years) were included in this 
      study. Basic echocardiographic measurements, left ventricular diastolic 
      parameters and left ventricular myocardial performance index (MPI) were measured. 
      The left ventricular MPI was calculated as (isovolumic contraction 
      time+isovolumic relaxation time)/aortic ejection time by Doppler. The urine 
      fluoride levels of fluorosis patients were significantly higher than control 
      subjects as expected (1.9+/-0.1mg/l vs 0.4+/-0.1mg/l respectively; P<0.001). 
      Isovolumic relaxation time (IVRT) and deceleration time (DT) were significantly 
      higher in fluorosis patients than in controls (for IVRT 106.9+/-15.6ms vs 
      96.7+/-12.2ms; P<0.001 and for DT 211.7+/-30.7ms vs 188.0+/-30.0ms; P<0.001, 
      respectively). MPI was significantly higher in fluorosis patients than in 
      controls (0.62+/-0.15ms vs 0.49+/-0.10ms; P<0.001, respectively). We have shown 
      that chronic fluorosis patients had left ventricular diastolic and global 
      dysfunctions.
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - Varol, Ercan
AU  - Varol E
AD  - Department of Cardiology, Faculty of Medicine, Suleyman Demirel University, 
      Isparta, Turkey. drercanvarol@yahoo.com
FAU - Akcay, Selahattin
AU  - Akcay S
FAU - Ersoy, I Hakki
AU  - Ersoy IH
FAU - Koroglu, Banu Kale
AU  - Koroglu BK
FAU - Varol, Simge
AU  - Varol S
LA  - eng
PT  - Journal Article
DEP - 20100305
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - Q80VPU408O (Fluorides)
SB  - IM
MH  - Adult
MH  - Chronic Disease
MH  - Diastole
MH  - Echocardiography, Doppler
MH  - Female
MH  - Fluorides/*adverse effects
MH  - Fluorosis, Dental/*physiopathology
MH  - Heart/*drug effects/physiopathology
MH  - Hemodynamics
MH  - Humans
MH  - Male
MH  - Myocardial Contraction/drug effects/physiology
MH  - Ventricular Dysfunction, Left/*chemically induced/physiopathology
MH  - Ventricular Function, Left/*physiology
EDAT- 2010/03/09 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/03/09 06:00
PHST- 2009/08/20 00:00 [received]
PHST- 2010/01/17 00:00 [revised]
PHST- 2010/02/04 00:00 [accepted]
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - S0048-9697(10)00122-1 [pii]
AID - 10.1016/j.scitotenv.2010.02.011 [doi]
PST - ppublish
SO  - Sci Total Environ. 2010 May 1;408(11):2295-8. doi: 
      10.1016/j.scitotenv.2010.02.011. Epub 2010 Mar 5.