PMID- 20206900
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20221017
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 16
IP  - 3
DP  - 2010 Mar
TI  - Functional electrical stimulation is more effective in severe symptomatic heart 
      failure patients and improves their adherence to rehabilitation programs.
PG  - 244-9
LID - 10.1016/j.cardfail.2009.10.023 [doi]
AB  - BACKGROUND: Functional electrical stimulation (FES) improves exercise capacity 
      and quality of life in chronic heart failure (CHF) patients. However, there is no 
      evidence regarding the effectiveness of this treatment modality according to the 
      severity of CHF. This study compares the effectiveness of FES on exercise 
      capacity, endothelial function, neurohormonal status, and emotional stress in New 
      York Heart Association (NYHA) III-IV versus NYHA II patients. METHODS AND 
      RESULTS: Eighteen NYHA II and 13 age- and sex-matched NYHA III-IV patients with 
      stable CHF (left ventricular ejection fraction <35%) underwent a 6-week FES 
      training program. Questionnaires addressing quality of life (Kansas City 
      Cardiomyopathy Questionnaire, functional and overall), and emotional stress (Zung 
      self-rating depression scale, Beck Depression Inventory), as well as plasma 
      B-type natriuretic peptide (BNP), 6-minute walking distance test (6MWT), and 
      endothelial function (flow-mediated dilatation [FMD]) were assessed at baseline 
      and after completion of training protocol. 6MWT and plasma BNP improved 
      significantly in 2 patient groups (both P < .001) after training program. The 
      improvement of BNP was statistically greater in NYHA III-IV patients 
      posttreatment than in those with NYHA II class (F=315.342, P < .001). Similarly, 
      the improvement of 6MWT was statistically greater in NYHA III-IV group than in 
      NYHA II patients (F=79.818, P < .001). Finally, an FES-induced greater 
      improvement of FMD (F=9.517, P=.004) and emotional stress scores was observed in 
      NYHA III-IV patients in comparison to NYHA II patients. There was a higher 
      proportion of NYHA III-IV patients adhering to the FES training program for 
      additional 3 months compared with the NYHA II group of patients (76.9% vs. 55.6%, 
      P < .001). CONCLUSION: FES might exert a greater beneficial effect on clinical 
      and neurohormonal status of NYHA III-IV patients in comparison to NYHA II 
      patients. This effect may have important clinical relevance leading to increased 
      adherence of severe CHF patients to exercise rehabilitation programs.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Karavidas, Apostolos
AU  - Karavidas A
AD  - Cardiology Department, General Hospital G.Genimmatas, Athens, Greece.
FAU - Parissis, John T
AU  - Parissis JT
FAU - Matzaraki, Vassiliki
AU  - Matzaraki V
FAU - Arapi, Sophia
AU  - Arapi S
FAU - Varounis, Christos
AU  - Varounis C
FAU - Ikonomidis, Ignatios
AU  - Ikonomidis I
FAU - Gkrilias, Panagiotis
AU  - Gkrilias P
FAU - Paraskevaidis, Ioannis
AU  - Paraskevaidis I
FAU - Pirgakis, Vlassios
AU  - Pirgakis V
FAU - Filippatos, Gerasimos
AU  - Filippatos G
FAU - Kremastinos, Dimitios T
AU  - Kremastinos DT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20091211
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Electric Stimulation Therapy/*methods
MH  - Exercise Therapy/*methods
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/classification/*rehabilitation/therapy
MH  - Heart Function Tests
MH  - Hemodynamics/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle Strength/physiology
MH  - Patient Compliance
MH  - Probability
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Treatment Outcome
EDAT- 2010/03/09 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/03/09 06:00
PHST- 2009/07/17 00:00 [received]
PHST- 2009/10/17 00:00 [revised]
PHST- 2009/10/21 00:00 [accepted]
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - S1071-9164(09)01144-0 [pii]
AID - 10.1016/j.cardfail.2009.10.023 [doi]
PST - ppublish
SO  - J Card Fail. 2010 Mar;16(3):244-9. doi: 10.1016/j.cardfail.2009.10.023. Epub 2009 
      Dec 11.