PMID- 20207162
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20220311
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 50
IP  - 2
DP  - 2010 May
TI  - Expression of cytokine genes in the aorta is altered by the deficiency in MCP-1: 
      effect of a high-fat, high-cholesterol diet.
PG  - 121-8
LID - 10.1016/j.cyto.2010.02.010 [doi]
AB  - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) facilitates the 
      recruitment of monocytes/macrophages into vascular intima, and it is probably 
      involved in the regulation of other signaling pathways relevant to the 
      pathogenesis of arteriosclerosis and metabolic disturbances. However, chemokines 
      are redundant. Consequently, the protective effect of MCP-1 deficiency may be 
      mediated by changes in other cytokine signals. METHODS AND RESULTS: Changes in 
      the pattern of gene expression in the aorta were evaluated in LDLr(-/-) and 
      MCP-1(-/-) LDLr(-/-) mice fed either chow or Western-style diet. Functional 
      analyses were used to characterize the pathways affected and to identify 
      biological processes in which MCP-1 may play an additional role. Some data also 
      suggest that MCP-5 may act as a surrogate for MCP-1 deletion. Arteriosclerosis 
      lesion and plaque composition are associated with enrichment in the 
      cytokine-cytokine receptor interaction pathway. CONCLUSIONS: There is a complex 
      network of interactions linking MCP-1 and other cytokines. The lack of MCP-1 
      limits the aortic response to atherogenic stimuli, but does not completely 
      protect against neointima formation. Activation of alternative inflammatory 
      pathways in the vascular wall in response to MCP-1 deficiency should be 
      considered to fully understand the actual role of this chemokine.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Rull, Anna
AU  - Rull A
AD  - Centre de Recerca Biomedica, Hospital Universitari Sant Joan de Reus, 
      IISPV-Institut d'Investigacio Sanitaria Pere Virgili, Universitat Rovira i 
      Virgili, c/Sant Joan s/n, Reus, Spain.
FAU - Beltran-Debon, Raul
AU  - Beltran-Debon R
FAU - Aragones, Gerard
AU  - Aragones G
FAU - Rodriguez-Sanabria, Fernando
AU  - Rodriguez-Sanabria F
FAU - Alonso-Villaverde, Carlos
AU  - Alonso-Villaverde C
FAU - Camps, Jordi
AU  - Camps J
FAU - Joven, Jorge
AU  - Joven J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100305
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Dietary Fats)
RN  - 0 (Receptors, LDL)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Animals
MH  - Aorta/*metabolism/pathology
MH  - Atherosclerosis/pathology
MH  - Chemokine CCL2/*deficiency/metabolism
MH  - Cholesterol/*pharmacology
MH  - Cluster Analysis
MH  - Cytokines/*genetics/metabolism
MH  - *Diet
MH  - Dietary Fats/*pharmacology
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation/*drug effects
MH  - Male
MH  - Mice
MH  - Protein Binding/drug effects
MH  - Receptors, LDL/metabolism
MH  - Time Factors
EDAT- 2010/03/09 06:00
MHDA- 2010/06/17 06:00
CRDT- 2010/03/09 06:00
PHST- 2009/11/17 00:00 [received]
PHST- 2010/01/26 00:00 [revised]
PHST- 2010/02/09 00:00 [accepted]
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
AID - S1043-4666(10)00036-0 [pii]
AID - 10.1016/j.cyto.2010.02.010 [doi]
PST - ppublish
SO  - Cytokine. 2010 May;50(2):121-8. doi: 10.1016/j.cyto.2010.02.010. Epub 2010 Mar 5.