PMID- 20208319
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20220330
IS  - 1590-8577 (Electronic)
IS  - 1590-8577 (Linking)
VI  - 11
IP  - 2
DP  - 2010 Mar 5
TI  - Methods and rationale for the early detection of pancreatic cancer. Highlights 
      from the "2010 ASCO Gastrointestinal Cancers Symposium". Orlando, FL, USA. 
      January 22-24, 2010.
PG  - 128-30
AB  - Pancreatic cancer often presents at an advanced stage that result in a very 
      dismal five-year survival rates. Novel methods to detect tumors as early as 
      possible are desperately needed. The U.S. Preventive Services Task Force (USPSTF) 
      recommends against routine screening for pancreatic cancer in asymptomatic adults 
      using abdominal palpation, ultrasonography, or serologic markers. The evidence 
      for diet-based prevention of pancreatic cancer is limited and conflicting. 
      Recommendations about lifestyle changes, such as stopping the use of tobacco 
      products, moderating alcohol intake, and eating a balanced diet with sufficient 
      fruit and vegetables is generally made. However, screening for persons with 
      hereditary predisposition to develop pancreatic cancer has not been included in 
      this review. Biomarkers represent one tool for the early detection of small, 
      surgically resectable cancers in both the general and high risk populations. Some 
      of the currently utilized biomarkers including carcinoembryonic antigen (CEA), CA 
      19-9, SPan-1, and DUPAN-2 unfortunately have yet to show the sensitivity and 
      specificity needed to be used for screening asymptomatic patients in the general 
      population for pancreatic cancer. Herein, the authors report some updated 
      information from the 2010 ASCO Gastrointestinal Cancers Symposium in detecting 
      early stage pancreatic cancer.
FAU - Bussom, Scott
AU  - Bussom S
AD  - Pharmacology Department, Yale University School of Medicine, New Haven, CT, USA. 
      wasif.saif@yale.edu
FAU - Saif, Muhammad Wasif
AU  - Saif MW
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100305
PL  - England
TA  - JOP
JT  - JOP : Journal of the pancreas
JID - 101091810
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Antibodies, Monoclonal/metabolism
MH  - Biomarkers, Tumor/analysis/blood
MH  - Carcinoma/*diagnosis/pathology
MH  - Congresses as Topic
MH  - Early Detection of Cancer/*methods/trends
MH  - Gastrointestinal Neoplasms/diagnosis/therapy
MH  - Humans
MH  - Immunoenzyme Techniques/methods
MH  - Neoplasm Staging
MH  - Pancreatic Neoplasms/*diagnosis/pathology
MH  - Rationalization
RF  - 21
EDAT- 2010/03/09 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/03/09 06:00
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - v11i02a05 [pii]
PST - epublish
SO  - JOP. 2010 Mar 5;11(2):128-30.