PMID- 20208320
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20100308
IS  - 1590-8577 (Electronic)
IS  - 1590-8577 (Linking)
VI  - 11
IP  - 2
DP  - 2010 Mar 5
TI  - Intraductal papillary mucinous neoplasia (IPMN). Highlights from the "2010 ASCO 
      Gastrointestinal Cancers Symposium". Orlando, FL, USA. January 22-24, 2010.
PG  - 131-4
AB  - The diagnosis and treatment of intraductal papillary mucinous tumors (IPMN) of 
      the pancreas has evolved over the last decade. IPMN is a disease of the ductal 
      epithelium and represent a spectrum of disease, ranging from benign to malignant 
      lesions, making the early detection and characterization of these lesions 
      important. As with villous adenomas of the colon, not all IPMNs will develop into 
      adenocarcinoma. Definitive management is surgical resection for appropriate 
      candidates, as benign lesions harbor malignant potential. Growing controversy 
      revolves around issues of natural history, management of small-branch-duct 
      lesions, ability to predict malignancy and/or progression, and surveillance 
      strategies. Given these controversies, novel methods are needed to help in 
      detecting and classifying IPMNs' malignant potential so that appropriate 
      treatment can be administered. The authors review abstracts from the 2010 ASCO 
      Gastrointestinal Cancers Symposium held in January 2010, including biomarkers 
      helping to classify IPMNs: IL-8 and IL-1beta from IPMN cyst aspirates (Abstract 
      #133), and Foxp3/CD4/CD25 cells (Abstract #148) in peripheral blood. Future 
      studies will hopefully provide insight into the many unanswered questions.
FAU - Bussom, Scott
AU  - Bussom S
AD  - Pharmacology Department, Yale University School of Medicine, New Haven, CT, USA. 
      wasif.saif@yale.edu
FAU - Saif, Muhammad Wasif
AU  - Saif MW
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100305
PL  - England
TA  - JOP
JT  - JOP : Journal of the pancreas
JID - 101091810
RN  - 0 (Cytokines)
SB  - IM
MH  - Adenocarcinoma, Mucinous/classification/diagnosis/pathology
MH  - Carcinoma, Pancreatic Ductal/classification/*diagnosis/*pathology
MH  - Carcinoma, Papillary/classification/diagnosis/pathology
MH  - Congresses as Topic
MH  - Cyst Fluid/chemistry
MH  - Cytokines/analysis
MH  - Early Detection of Cancer/methods
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Gastrointestinal Neoplasms/diagnosis
MH  - Humans
MH  - Models, Biological
MH  - Neoplasm Staging/methods
MH  - Pancreatic Neoplasms/classification/*diagnosis/*pathology
RF  - 26
EDAT- 2010/03/09 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/03/09 06:00
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - v11i02a06 [pii]
PST - epublish
SO  - JOP. 2010 Mar 5;11(2):131-4.