PMID- 20208403
OWN - NLM
STAT- MEDLINE
DCOM- 20100615
LR  - 20191111
IS  - 1882-1006 (Electronic)
IS  - 0015-6426 (Linking)
VI  - 51
IP  - 1
DP  - 2010
TI  - [LC/ESI-MS/MS method for the simultaneous determination of macrocyclic lactone 
      parasiticides in livestock products and fish].
PG  - 1-9
AB  - An LC/ESI (positive-mode)-MS/MS method was developed for simultaneous 
      quantification of 8 macrocyclic lactones (abamectin B1a, abamectin 8,9-Z isomer 
      B1a, emamectin benzoate B1a, emamectin benzoate 8,9-Z isomer B1a, ivermectin, 
      eprinomectin B1a, doramectin and moxidectin) in animal tissues, egg, milk and 
      honey. The separation was achieved on a TSK-GEL ODS 100 V column (2.0 x 50 mm, 3 
      microm) with a mobile phase consisting of 0.1% formic acid in acetonitrile, and 
      0.1 mM ammonium formate-0.1% formic acid in water, at a flow rate of 0.2 mL/min 
      with gradient elution. Linear calibration plots were obtained with high 
      correlation coefficients (r=0.998-0.999). The LOQ and LOD ranged from 0.02-1.5 
      ng/mL and 0.1-5 ng/mL, respectively. Average recoveries were in the range of 
      70.8-117.1% with associated RSD values<15% (n=10) for repeatability and 
      reproducibility. The spiking levels for recoveries and RSDs met the validation 
      criteria for Japanese maximum residue limits (MRLs). Based on these results, the 
      proposed analytical method has been proven to be highly efficient and suitable 
      for routine determinations of macrocyclic lactones in animal food matrices.
FAU - Inoue, Koichi
AU  - Inoue K
AD  - Department of Physical and Analytical Chemistry, School of Pharmacy, Kinjo Gakuin 
      University, 2-1723 Omori, Moriyama-ku, Nagoya 463-8521, Japan.
FAU - Yoshimi, Yukiko
AU  - Yoshimi Y
FAU - Hino, Tomoaki
AU  - Hino T
FAU - Oka, Hisao
AU  - Oka H
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Shokuhin Eiseigaku Zasshi
JT  - Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan
JID - 0142214
RN  - 0 (Antiparasitic Agents)
RN  - 0 (Lactones)
RN  - 0 (Pesticide Residues)
SB  - IM
MH  - Animals
MH  - Antiparasitic Agents/*analysis
MH  - Chromatography, Liquid/instrumentation/*methods
MH  - Eggs/analysis
MH  - Fish Products/*analysis
MH  - Food Analysis/instrumentation/*methods
MH  - Honey/analysis
MH  - Lactones/*analysis
MH  - Meat Products/*analysis
MH  - Milk/chemistry
MH  - Pesticide Residues/*analysis
MH  - Tandem Mass Spectrometry/instrumentation/*methods
EDAT- 2010/03/09 06:00
MHDA- 2010/06/16 06:00
CRDT- 2010/03/09 06:00
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/06/16 06:00 [medline]
AID - JST.JSTAGE/shokueishi/51.1 [pii]
AID - 10.3358/shokueishi.51.1 [doi]
PST - ppublish
SO  - Shokuhin Eiseigaku Zasshi. 2010;51(1):1-9. doi: 10.3358/shokueishi.51.1.