PMID- 20209990
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20131121
IS  - 0042-4625 (Print)
IS  - 0042-4625 (Linking)
VI  - 168
IP  - 6
DP  - 2009
TI  - [Features of allele polymorphism of genes involved in homocysteine and folate 
      metabolism in patients with atherosclerosis of the lower extremity arteries].
PG  - 41-4
AB  - Under study were features of allele polymorphism of genes of 
      methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase 
      (MS A 2756G), methionine synthase reductase (MTRR A66G) and 
      methylenetetrahydrofolate dehydrogenase (MTHFD G1958A) in patients with 
      atherosclerosis of the lower extremity arteries (ALEA). Patients with 
      hyperhomocysteinemia (HHcy) had statistically significant increase of allele 
      MTHFR 677T and MTRR 66GG as compared both with the control group and with the 
      group of patients without HHcy. It suggests that polymorphism of genes involved 
      in homocystein and folate metabolism might affect the risk of HHcy in patients 
      with ALEA.
FAU - Klenkova, N A
AU  - Klenkova NA
FAU - Kapustin, S I
AU  - Kapustin SI
FAU - Saltykova, N B
AU  - Saltykova NB
FAU - Shmeleva, V M
AU  - Shmeleva VM
FAU - Blinov, M N
AU  - Blinov MN
LA  - rus
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Vestn Khir Im I I Grek
JT  - Vestnik khirurgii imeni I. I. Grekova
JID - 0411377
RN  - 0 (Flavoproteins)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 77921-44-9 (5,11-methenyltetrahydrohomofolate)
RN  - 9007-49-2 (DNA)
RN  - 935E97BOY8 (Folic Acid)
RN  - EC 1.18.1.- (methionine synthase reductase)
RN  - EC 1.18.1.2 (Ferredoxin-NADP Reductase)
SB  - IM
MH  - Alleles
MH  - Atherosclerosis/blood/diagnosis/*genetics
MH  - DNA/*genetics
MH  - Female
MH  - Ferredoxin-NADP Reductase/genetics
MH  - Flavoproteins
MH  - Folic Acid/analogs & derivatives/blood/*genetics
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Homocysteine/blood/*genetics
MH  - Humans
MH  - Leg/*blood supply
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Prognosis
MH  - Severity of Illness Index
EDAT- 2009/01/01 00:00
MHDA- 2010/05/05 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2009/01/01 00:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
PST - ppublish
SO  - Vestn Khir Im I I Grek. 2009;168(6):41-4.