PMID- 20210781
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20191111
IS  - 1873-4251 (Electronic)
IS  - 1570-162X (Linking)
VI  - 8
IP  - 1
DP  - 2010 Jan
TI  - Virulence determinants of equine infectious anemia virus.
PG  - 66-72
AB  - Equine infectious anemia virus (EIAV) is a macrophage-tropic lentivirus that 
      rapidly Induces disease in experimentally infected horses. Because EIAV infection 
      and replication is centered on the monocyte/macrophage and has a pronounced acute 
      disease stage, it is a useful model system for understanding the contribution of 
      monocyte/macrophages to other lentivirus-induced diseases. Genetic mapping 
      studies utilizing chimeric proviruses in which parental viruses are acutely 
      virulent or avirulent have allowed the identification of important regions that 
      influence acute virulence. U3 regions in the viral LTR, surface envelope (SU) 
      protein and the accessory S2 gene strongly influence acute disease expression. 
      While the chimeric proviruses provide insight into genes or genome regions that 
      affect viral pathogenesis, it is then necessary to further dissect those regions 
      to focus on specific virus-host mechanisms that lead to disease expression. The 
      V6 region of the viral env protein is an example of one identified region that 
      may interact with the ELR-1 receptor in an important way and we are currently 
      identifying S2 protein motifs required for disease expression.
FAU - Payne, Susan L
AU  - Payne SL
AD  - Department of Pathobiology, College of Veterinary Medicine, Texas A & M 
      University, 4467 TAMU, College Station, TX 77843-4467, USA. spayne@cvm.tamu.edu
FAU - Fuller, Frederick J
AU  - Fuller FJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Curr HIV Res
JT  - Current HIV research
JID - 101156990
RN  - 0 (Virulence Factors)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Equine Infectious Anemia/*virology
MH  - Horses
MH  - Host-Pathogen Interactions
MH  - Infectious Anemia Virus, Equine/genetics/*pathogenicity
MH  - Macrophages
MH  - Terminal Repeat Sequences
MH  - Viral Tropism
MH  - *Virulence Factors
MH  - *Virus Replication
RF  - 41
EDAT- 2010/03/10 06:00
MHDA- 2010/07/02 06:00
CRDT- 2010/03/10 06:00
PHST- 2009/09/22 00:00 [received]
PHST- 2009/11/02 00:00 [accepted]
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
AID - ABS-44 [pii]
AID - 10.2174/157016210790416352 [doi]
PST - ppublish
SO  - Curr HIV Res. 2010 Jan;8(1):66-72. doi: 10.2174/157016210790416352.