PMID- 20210919
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20111117
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 75
IP  - 6
DP  - 2010 Jun
TI  - HLA-DQA1*0505 sharing and killer immunoglobulin-like receptors in sub fertile 
      couples: report from the 15th International Histocompatibility Workshop.
PG  - 668-72
LID - 10.1111/j.1399-0039.2010.01451.x [doi]
AB  - This aim of the study was to investigate whether human leukocyte antigen 
      (HLA)-DQA1*0505 sharing or the maternal killer immunoglobulin-like receptor (KIR) 
      repertoire is associated with recurrent spontaneous abortion (RSA) or repeated 
      implantation failure (RIF). The study included 224 couples with RSA, 61 couples 
      with RIF, 182 fertile couples, and 10 couples with successful in vitro 
      fertilization and embryo transfer (IVF)/ET at first cycle. HLA-DQA1*0505 typing 
      using polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSO) was 
      performed in 185 RSA (117 with alloimmune abnormalities and 68 of autoimmune 
      etiology), 61 RIF and 182 control couples, and KIR genotyping using polymerase 
      chain reaction-sequence-specific primer (PCR-SSP) in 167 RSA and 55 RIF cases as 
      well as 46 RSA and 10 IVF controls. No differences in DQA1*0505 sharing were 
      found between patients and controls. In RSA and RIF women, the ratio of 
      inhibitory to activating KIRs was slightly lower (1.53 and 1.85 vs 2.03 in 
      controls). The analysis of maternal inhKIR and fetal HLA-C molecule pairs showed 
      that the 'less inhibiting' combination KIR2DL3-C1 was found in higher percentage 
      in subfertile (mainly RIF) than in fertile couples. In contrast, the percentage 
      of cases possessing the 'strong inhibiting' combination KIR2DL1-C2 was lower in 
      the RSA and RIF groups in comparison with that in the control groups (17.36% vs 
      23.91 and 16.36% vs 40%, respectively). In women with >or= 6 implantation 
      failures, the KIR2DL1-C2 combination was not found in any of them (P = 0.0014), 
      and the KIR2DL3-C1 combination was not found in the control IVF group. The 
      results oppose the suggestion that increased HLA-DQA1*0505 sharing predispose to 
      RSA or RIF. The KIR2DL3-C1 combination (or lack of the KIR2DL1-C2 one) is 
      associated with implantation failure.
FAU - Varla-Leftherioti, M
AU  - Varla-Leftherioti M
AD  - Immunobiology Department, Helena Venizelou Maternity Hospital, Athens, Greece. 
      gr1bmdr@hol.gr
FAU - Keramitsoglou, T
AU  - Keramitsoglou T
FAU - Parapanissiou, E
AU  - Parapanissiou E
FAU - Kurpisz, M
AU  - Kurpisz M
FAU - Kontopoulou-Antonopoulou, V
AU  - Kontopoulou-Antonopoulou V
FAU - Tsekoura, C
AU  - Tsekoura C
FAU - Kamieniczna, M
AU  - Kamieniczna M
FAU - Novokowska, B
AU  - Novokowska B
FAU - Paparistidis, N
AU  - Paparistidis N
FAU - Vrani, V
AU  - Vrani V
FAU - Daniilidis, M
AU  - Daniilidis M
FAU - Spyropoulou-Vlachou, M
AU  - Spyropoulou-Vlachou M
LA  - eng
PT  - Journal Article
DEP - 20100304
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Abortion, Habitual/*genetics/immunology
MH  - Abortion, Spontaneous/*genetics/immunology
MH  - Adult
MH  - Autoimmune Diseases/*genetics
MH  - Autoimmunity/*genetics
MH  - Embryo Implantation/genetics
MH  - Embryo Transfer
MH  - Female
MH  - Fertilization in Vitro
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Maternal-Fetal Relations
MH  - Receptors, KIR/*genetics
MH  - Young Adult
EDAT- 2010/03/10 06:00
MHDA- 2010/09/25 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - TAN1451 [pii]
AID - 10.1111/j.1399-0039.2010.01451.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2010 Jun;75(6):668-72. doi: 10.1111/j.1399-0039.2010.01451.x. 
      Epub 2010 Mar 4.