PMID- 20210922
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 76
IP  - 1
DP  - 2010 Jul
TI  - The frequency of DRB1*1454 in South German Caucasians.
PG  - 57-9
LID - 10.1111/j.1399-0039.2010.01461.x [doi]
AB  - Human leukocyte antigen (HLA)-DRB1*1454 differs from HLA-DRB1*1401 in only one 
      position in exon 3. Before description of this polymorphism both alleles were 
      routinely typed as HLA-DRB1*1401. This prompted our study on relative frequency 
      of these alleles. We determined relative frequencies of DRB1*1454 and DRB1*1401 
      by sequence-based tying (SBT) in 106 samples and found DRB1*1454 in 87.9% and 
      DRB1*1401 in 12.1% of previously DRB1*1401/54 ambiguous tested individuals. 
      Population frequencies were estimated using data from the local bone marrow donor 
      database. Phenotype and genotype frequency of DRB1*1454 and DRB1*1401 were 
      5.592%, 0.2828, and 0.773%, 0.00391, respectively. The corresponding figures for 
      DRB1*1404 were 0.238% and 0.00119. Other DRB1*14 alleles were very rare. The most 
      frequent haplotype was DRB1*1454-DRB3*0202-DQB1*0503. Although DRB1*1454 is 
      almost exclusively associated with DRB3*0202, DRB1*1401 is linked with either 
      DRB3*0201 or DRB3*0202. HLA-DRB1*1454 is the most common DRB1*14 allele among 
      German Caucasians and should be considered as a preferred allele over DRB1*1401.
FAU - Furst, D
AU  - Furst D
AD  - German Red Cross Blood Donation Service, Baden-Wuerttemberg-Hessen, Ulm, Germany. 
      d.fuerst@blutspende.de
FAU - Solgi, G
AU  - Solgi G
FAU - Schrezenmeier, H
AU  - Schrezenmeier H
FAU - Mytilineos, J
AU  - Mytilineos J
LA  - eng
PT  - Journal Article
DEP - 20100304
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*14:54 antigen)
SB  - IM
MH  - *Gene Frequency
MH  - Genotype
MH  - Germany
MH  - HLA-DR Antigens/*genetics/immunology
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Phenotype
MH  - White People/*genetics
EDAT- 2010/03/10 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - TAN1461 [pii]
AID - 10.1111/j.1399-0039.2010.01461.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2010 Jul;76(1):57-9. doi: 10.1111/j.1399-0039.2010.01461.x. Epub 
      2010 Mar 4.