PMID- 20211168
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20220129
IS  - 1090-2422 (Electronic)
IS  - 0014-4827 (Linking)
VI  - 316
IP  - 9
DP  - 2010 May 15
TI  - Portal venous endothelium in developing human liver contains haematopoietic and 
      epithelial progenitor cells.
PG  - 1637-47
LID - 10.1016/j.yexcr.2010.02.025 [doi]
AB  - Future treatments for chronic liver disease are likely to involve manipulation of 
      liver progenitor cells (LPCs). In the human, data characterising the regenerative 
      response is limited and the origin of adult LPCs is unknown. However, these 
      remain critical factors in the design of cell-based liver therapies. The 
      developing human liver provides an ideal model to study cell lineage derivation 
      from progenitors and to understand how foetal haematopoiesis and liver 
      development might explain the nature of the adult LPC population. In 1st 
      trimester human liver, portal venous endothelium (PVE) expressed adult LPC 
      markers and markers of haematopoietic progenitor cells (HPCs) shared with 
      haemogenic endothelium found in the embryonic dorsal aorta. Sorted PVE cells were 
      able to generate hepatoblast-like cells co-expressing CK18 and CK19 in addition 
      to Dlk/pref-1, E-cadherin, albumin and fibrinogen in vitro. Furthermore, PVE 
      cells could initiate haematopoiesis. These data suggest that PVE shares 
      phenotypical and functional similarities both with adult LPCs and embryonic 
      haemogenic endothelium. This indicates that a temporal relationship might exist 
      between progenitor cells in foetal liver development and adult liver 
      regeneration, which may involve progeny of PVE.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Terrace, John D
AU  - Terrace JD
AD  - Centre for Regenerative Medicine, University of Edinburgh Medical School, 
      Edinburgh, Scotland, UK.
FAU - Hay, David C
AU  - Hay DC
FAU - Samuel, Kay
AU  - Samuel K
FAU - Anderson, Richard A
AU  - Anderson RA
FAU - Currie, Ian S
AU  - Currie IS
FAU - Parks, Rowan W
AU  - Parks RW
FAU - Forbes, Stuart J
AU  - Forbes SJ
FAU - Ross, James A
AU  - Ross JA
LA  - eng
GR  - MC_U127684439/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100306
PL  - United States
TA  - Exp Cell Res
JT  - Experimental cell research
JID - 0373226
RN  - 0 (Biomarkers)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Cell Lineage
MH  - Colony-Forming Units Assay
MH  - Endothelium, Vascular/*cytology/physiology
MH  - Epithelial Cells/*physiology
MH  - Female
MH  - Fetus/metabolism
MH  - Fluorescent Antibody Technique
MH  - Hematopoiesis
MH  - Hematopoietic Stem Cells/cytology/*physiology
MH  - Humans
MH  - Liver/*embryology/physiology
MH  - Phenotype
MH  - Portal Vein/*cytology/physiology
MH  - Pregnancy
MH  - Pregnancy Trimester, First
MH  - RNA, Messenger/genetics/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Stem Cells/*physiology
EDAT- 2010/03/10 06:00
MHDA- 2010/06/04 06:00
CRDT- 2010/03/10 06:00
PHST- 2009/11/25 00:00 [received]
PHST- 2010/02/22 00:00 [revised]
PHST- 2010/02/24 00:00 [accepted]
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - S0014-4827(10)00087-X [pii]
AID - 10.1016/j.yexcr.2010.02.025 [doi]
PST - ppublish
SO  - Exp Cell Res. 2010 May 15;316(9):1637-47. doi: 10.1016/j.yexcr.2010.02.025. Epub 
      2010 Mar 6.