PMID- 20211214
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20221109
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 6
DP  - 2010 Jun
TI  - Development of antibodies to human leukocyte antigen precedes development of 
      antibodies to major histocompatibility class I-related chain A and are 
      significantly associated with development of chronic rejection after human lung 
      transplantation.
PG  - 560-5
LID - 10.1016/j.humimm.2010.02.021 [doi]
AB  - The development of antibodies (Abs) to major histocompatibility (MHC) class 
      I-related chain A (MICA) and human leukocyte antigen (HLA) and their role in the 
      immunopathogenesis of chronic rejection (bronchiolitis obliterans syndrome [BOS]) 
      after human lung transplantation (LTx) was analyzed. Sera from 80 LTx recipients 
      were analyzed for anti-MICA and anti-HLA Abs using Luminex and flow PRA (panel 
      reactive assay). Development of Abs either to MICA alone or MICA and HLA together 
      significantly correlated (p < 0.01) with development of BOS. Kinetic analysis in 
      the post-LTx period revealed that development of anti-HLA Abs (7.6 +/- 4.7 
      months) preceded the development of anti-MICA Abs (10.0 +/- 3.5 months). Abs to 
      MICA alleles (*001 and *009) developed approximately 6 months after LTx and peak 
      titers were present at the time of clinical diagnosis of BOS (16.3 +/- 2.7 
      months). The development of Abs to both MICA and HLA was strongly associated with 
      the development of BOS thereby suggesting a synergistic effect. Furthermore, 
      immune response to mismatched HLA can lead to development of Abs to other MHC 
      related antigens expressed on the airway epithelial cells. Cumulatively, these 
      immune responses contribute to the pathogenesis of chronic rejection following 
      human LTx.
CI  - Copyright 2010 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Angaswamy, Nataraju
AU  - Angaswamy N
AD  - Department of Surgery, Washington University School of Medicine, St. Louis, 
      Missouri, USA.
FAU - Saini, Deepti
AU  - Saini D
FAU - Ramachandran, Sabarinathan
AU  - Ramachandran S
FAU - Nath, Dilip S
AU  - Nath DS
FAU - Phelan, Donna
AU  - Phelan D
FAU - Hachem, Ramsey
AU  - Hachem R
FAU - Trulock, Elbert
AU  - Trulock E
FAU - Patterson, G Alexander
AU  - Patterson GA
FAU - Mohanakumar, T
AU  - Mohanakumar T
LA  - eng
GR  - R01 HL056643/HL/NHLBI NIH HHS/United States
GR  - T32-HL07776/HL/NHLBI NIH HHS/United States
GR  - HL056643/HL/NHLBI NIH HHS/United States
GR  - T32 HL007776/HL/NHLBI NIH HHS/United States
GR  - R01 HL056643-13A1/HL/NHLBI NIH HHS/United States
GR  - T32 HL007776-15/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100316
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Autoantigens)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Immunoglobulins)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - Adult
MH  - Antibody Formation
MH  - Autoantigens/*immunology
MH  - Bronchiolitis Obliterans
MH  - Female
MH  - Graft Rejection/blood/*immunology/physiopathology
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Immunoglobulins/blood
MH  - Lung Transplantation
MH  - Male
MH  - Middle Aged
MH  - Respiratory Mucosa/immunology/*metabolism
PMC - PMC2874120
MID - NIHMS186911
EDAT- 2010/03/10 06:00
MHDA- 2010/10/01 06:00
PMCR- 2011/06/01
CRDT- 2010/03/10 06:00
PHST- 2009/12/02 00:00 [received]
PHST- 2010/02/09 00:00 [revised]
PHST- 2010/02/18 00:00 [accepted]
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
PHST- 2011/06/01 00:00 [pmc-release]
AID - S0198-8859(10)00064-9 [pii]
AID - 10.1016/j.humimm.2010.02.021 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Jun;71(6):560-5. doi: 10.1016/j.humimm.2010.02.021. Epub 2010 
      Mar 16.