PMID- 20211906
OWN - NLM
STAT- MEDLINE
DCOM- 20100402
LR  - 20111117
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 74
IP  - 10
DP  - 2010 Mar 9
TI  - Increased frequency of HLA-DRB1*15 in patients with multifocal motor neuropathy.
PG  - 828-32
LID - 10.1212/WNL.0b013e3181d3e2f6 [doi]
AB  - OBJECTIVES: The favorable response to treatment with IV immunoglobulins and the 
      presence of IgM antibodies to the glycolipid GM1 are indications that 
      inflammation underlies multifocal motor neuropathy (MMN) pathogenesis. We 
      investigated the association of MMN with human leukocyte antigen (HLA) class I 
      and II antigens. METHODS: HLA class I and II antigens of 74 Dutch patients with 
      MMN and 700 controls were determined in a case-control study. Associations of HLA 
      types with MMN disease characteristics were investigated. RESULTS: Compared with 
      controls, patients with MMN had higher frequencies of HLA-DRB1*15 (41 vs 24%, p = 
      0.0017). Disease characteristics were not associated with specific HLA types. 
      CONCLUSIONS: Similar associations were found in patients with multiple sclerosis 
      and women with chronic immune-mediated demyelinating neuropathy, which may 
      suggest that these demyelinating disorders share pathogenic mechanisms.
FAU - Sutedja, N A
AU  - Sutedja NA
AD  - Department of Neurology, G03.228, University Medical Center Utrecht, PO Box 
      85500, 3508 GA Utrecht, the Netherlands.
FAU - Otten, H G
AU  - Otten HG
FAU - Cats, E A
AU  - Cats EA
FAU - Piepers, S
AU  - Piepers S
FAU - Veldink, J H
AU  - Veldink JH
FAU - van der Pol, W L
AU  - van der Pol WL
FAU - van den Berg, L H
AU  - van den Berg LH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Membrane Glycoproteins)
RN  - 37758-47-7 (G(M1) Ganglioside)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Brachial Plexus/pathology
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Female
MH  - G(M1) Ganglioside/immunology
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Immunoglobulin M/blood
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Membrane Glycoproteins/*genetics
MH  - Middle Aged
MH  - Multiple Sclerosis/*genetics/pathology/physiopathology
MH  - Neural Conduction/physiology
MH  - Polyradiculoneuropathy, Chronic Inflammatory 
      Demyelinating/*genetics/pathology/physiopathology
MH  - Retrospective Studies
EDAT- 2010/03/10 06:00
MHDA- 2010/04/03 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/04/03 06:00 [medline]
AID - 74/10/828 [pii]
AID - 10.1212/WNL.0b013e3181d3e2f6 [doi]
PST - ppublish
SO  - Neurology. 2010 Mar 9;74(10):828-32. doi: 10.1212/WNL.0b013e3181d3e2f6.