PMID- 20213614
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20190917
IS  - 1120-6721 (Print)
IS  - 1120-6721 (Linking)
VI  - 20
IP  - 4
DP  - 2010 Jul-Aug
TI  - Intravitreal ranibizumab for choroidal neovascularization associated with retinal 
      astrocytic hamartoma.
PG  - 789-91
AB  - PURPOSE: To report on a patient with retinal astrocytic hamartoma, who developed 
      a choroidal neovascularization (CNV), effectively treated by intravitreal 
      ranibizumab injections. METHODS: A 74-year-old woman who, 12 years before, had 
      been diagnosed with a yellow-gray lesion in the left eye (OS) presented in our 
      department for OS decreased vision of recent onset. RESULTS: Upon a complete 
      ophthalmologic examination including ultrasonography, fluorescein angiography 
      (FA), and spectral domain optical coherence tomography (SD-OCT), the patient was 
      diagnosed with retinal astrocytic hamartoma and coincident CNV on its foveal 
      border. Six months after 3 monthly intravitreal ranibizumab injections, FA and 
      OCT revealed the CNV closure and absence of intraretinal and subretinal fluid on 
      the foveal border of the retinal astrocytic hamartoma. CONCLUSIONS: Associations 
      between retinal astrocytic hamartoma and CNV have not been previously reported. 
      Intravitreal ranibizumab injection appears an attractive therapeutic option for 
      patients showing such an unusual association.
FAU - Querques, Giuseppe
AU  - Querques G
AD  - Department of Ophthalmology, Hopital Intercommunal de Creteil, University Paris 
      XII, Paris, France. giuseppe.querques@hotmail.it
FAU - Kerrate, Houda
AU  - Kerrate H
FAU - Leveziel, Nicolas
AU  - Leveziel N
FAU - Coscas, Gabriel
AU  - Coscas G
FAU - Soubrane, Gisele
AU  - Soubrane G
FAU - Souied, Eric H
AU  - Souied EH
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - ZL1R02VT79 (Ranibizumab)
SB  - IM
MH  - Aged
MH  - Angiogenesis Inhibitors/*administration & dosage
MH  - Antibodies, Monoclonal/*administration & dosage
MH  - Antibodies, Monoclonal, Humanized
MH  - Choroidal Neovascularization/diagnosis/*drug therapy/etiology
MH  - Female
MH  - Fluorescein Angiography
MH  - Follow-Up Studies
MH  - Hamartoma/*complications/diagnosis
MH  - Humans
MH  - Intravitreal Injections
MH  - Ranibizumab
MH  - Retinal Diseases/*complications/diagnosis
MH  - Tomography, Optical Coherence
MH  - Visual Acuity
EDAT- 2010/03/10 06:00
MHDA- 2011/06/24 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - 9F2E22C9-80B7-4485-A0BA-432306C20C8D [pii]
AID - 10.1177/112067211002000424 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2010 Jul-Aug;20(4):789-91. doi: 10.1177/112067211002000424.