PMID- 20214214
OWN - NLM
STAT- MEDLINE
DCOM- 20100325
LR  - 20131121
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 56
IP  - 96
DP  - 2009 Nov-Dec
TI  - Clinical study of upper gastrointestinal bleeding associated with low-dose 
      aspirin in Japanese patients.
PG  - 1665-9
AB  - BACKGROUND/AIMS: The aim of this study was to clarify the prevalence and various 
      clinical factors of upper gastrointestinal bleeding (UGIB) associated with 
      low-dose aspirin (LDA) treatment. METHODOLOGY: There were 6,807 patients who were 
      under treatment with LDA at our hospital between January 2003 and November 2007. 
      They had kept taking the LDA or started treatment in the study period and kept 
      taking the whole period of observation. Esophagogastroduodenoscopy (EGD) was 
      performed 453 patients of these patients, and 71 were diagnosed as LDA-associated 
      UGIB. We examined the prevalence and various clinical factors of UGIB associated 
      with LDA treatment. RESULTS: The occurrence rate of UGIB was 0.209 UGIB per 100 
      patient-years at least. The multivariate odds ratio of LDA-associated UGIB was 
      3.318 (95% confidence interval (CI) 1.650-6.671, p = 0.0008) for a history of 
      peptic ulcer, 0.086 (95% CI: 0.011-0.652, p = 0.0176) for the use of a proton 
      pump inhibitor (PPI) with LDA, and 0.253 (95% CI: 0.113-0.569, p = 0.0009) for 
      the use of a histamine type 2 receptor antagonist (H2RA) with LDA. CONCLUSIONS: 
      Our results suggest that a history of peptic ulcer significantly increases the 
      risk of LDA-associated UGIB. Regular use of a PPI or a H2RA effectively decreases 
      the risk.
FAU - Okada, Kazuhisa
AU  - Okada K
AD  - Division of Gastroenterology, Hiratsuka City Hospital, Hiratsuka, Japan.
FAU - Inamori, Masahiko
AU  - Inamori M
FAU - Imajo, Kento
AU  - Imajo K
FAU - Chiba, Hideyuki
AU  - Chiba H
FAU - Nonaka, Takashi
AU  - Nonaka T
FAU - Shiba, Tadahiko
AU  - Shiba T
FAU - Sakaguchi, Takashi
AU  - Sakaguchi T
FAU - Atsukawa, Kazuhiro
AU  - Atsukawa K
FAU - Takahashi, Hisao
AU  - Takahashi H
FAU - Hoshino, Etsuo
AU  - Hoshino E
FAU - Nakajima, Atsushi
AU  - Nakajima A
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Inflammatory Agents, Non-Steroidal/*adverse effects
MH  - Aspirin/*adverse effects
MH  - Female
MH  - Gastrointestinal Hemorrhage/*chemically induced
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Peptic Ulcer/complications
MH  - Risk Factors
EDAT- 2010/03/11 06:00
MHDA- 2010/03/26 06:00
CRDT- 2010/03/11 06:00
PHST- 2010/03/11 06:00 [entrez]
PHST- 2010/03/11 06:00 [pubmed]
PHST- 2010/03/26 06:00 [medline]
PST - ppublish
SO  - Hepatogastroenterology. 2009 Nov-Dec;56(96):1665-9.