PMID- 20214500
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20181201
IS  - 1557-7716 (Electronic)
IS  - 1523-0864 (Linking)
VI  - 13
IP  - 4
DP  - 2010 Aug 15
TI  - Redox Pioneer: Professor Gregg L. Semenza.
PG  - 559-64
LID - 10.1089/ars.2010.3155 [doi]
AB  - Dr. Gregg L. Semenza is recognized here as a Redox Pioneer because he has 
      published three articles that have been cited more than 1,000 times, and 74 
      articles that have each been cited more than 100 times. Dr. Semenza is known for 
      his seminal discovery of hypoxia-inducible factor-1 (HIF-1) and for identifying 
      molecular mechanisms underlying transcriptional responses to hypoxia. The 
      discovery of HIF-1 is regarded as a fundamental breakthrough in understanding the 
      molecular basis of O(2) sensing, and led to the identification of related 
      transcriptional activators now known as the HIF family, which are the focus of 
      many investigator's studies around the world. Understanding the molecular basis 
      of cellular responses to hypoxia is of immense physiological significance and has 
      tremendous implications for medicine. Compelling evidence now exists for the 
      involvement of HIF-1 signaling in the progression of cancer, cardiovascular 
      morbidities associated with aging and diabetes, and pulmonary vascular remodeling 
      in response to chronic hypoxia. Dr. Semenza's findings have led to the 
      development of inhibitors of the HIF-1 signaling pathway, which are currently 
      being tested for treatment of cancer. He has received several honors for his 
      scientific contributions, including the 2010 Gairdner Foundation International 
      Award and election to the National Academy of Sciences of the United States of 
      America.
FAU - Prabhakar, Nanduri R
AU  - Prabhakar NR
AD  - Department of Medicine, University of Chicago, Chicago, IL, USA. 
      nanduri@uchicago.edu
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
PL  - United States
TA  - Antioxid Redox Signal
JT  - Antioxidants & redox signaling
JID - 100888899
RN  - 0 (Hypoxia-Inducible Factor 1)
SB  - IM
MH  - Genetics, Medical/history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Hypoxia-Inducible Factor 1/genetics/metabolism
MH  - *Oxidation-Reduction
MH  - Signal Transduction/genetics/physiology
MH  - United States
PS  - Semenza GL
FPS - Semenza, Gregg L
EDAT- 2010/03/11 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/03/11 06:00
PHST- 2010/03/11 06:00 [entrez]
PHST- 2010/03/11 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - 10.1089/ars.2010.3155 [doi]
PST - ppublish
SO  - Antioxid Redox Signal. 2010 Aug 15;13(4):559-64. doi: 10.1089/ars.2010.3155.