PMID- 20214848
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20200721
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 31
IP  - 2
DP  - 2010 Mar-Apr
TI  - Human leukocyte antigen type and progression from onset of symptoms to 
      development of asthma.
PG  - 120-5
LID - 10.2500/aap.2010.31.3321 [doi]
AB  - This study investigated the influence of human leukocyte antigen (HLA) genes on 
      the progression of asthma, from the initial onset of symptoms to when criteria 
      for asthma are met. Study subjects were a subsample (n = 340) of 838 healthy 
      children, aged 5-12 years, who participated in a previous study, and who had HLA 
      data and asthma status. The duration in time from the initial onset of asthma 
      symptoms documented in each subject's medical records to the index date when the 
      subject first met criteria for asthma was determined. The time duration was 
      compared between carriers and noncarriers of HLA genes of interest of the 340 
      original subjects with HLA data available, 114 children (33.5%) met criteria for 
      asthma before 18 years of age. The median ages at onset of asthma symptoms and at 
      the index date of asthma were 4.4 years and 7.2 years, respectively. The median 
      time intervals between onset of symptoms and index date for HLA DRB1*11 carriers 
      and noncarriers were 552 versus 61 days, respectively (p = 0.004). The same time 
      intervals for HLA DQB1*0301 carriers and noncarriers were 420 versus 59 days, 
      respectively (p = 0.012). However, HLA DQB1*0302 or DRB1*03 carriers had shorter 
      median intervals, when compared with noncarriers (119 versus 266 days, 
      respectively, p = 0.20; and 86 versus 258 days, respectively, p = 0.38) but they 
      did not reach statistical significance. HLA type appears to influence the 
      progression of asthma from initial symptoms to disease. Thus, genetic factors may 
      affect the natural history of asthma.
FAU - Martyn, Molly B
AU  - Martyn MB
AD  - University of Washington, Seattle, Washington, USA.
FAU - Molis, Whitney
AU  - Molis W
FAU - Jacobson, Robert M
AU  - Jacobson RM
FAU - Poland, Gregory A
AU  - Poland GA
FAU - Weaver, Amy L
AU  - Weaver AL
FAU - Juhn, Young J
AU  - Juhn YJ
LA  - eng
GR  - R01 AI033144/AI/NIAID NIH HHS/United States
GR  - R01 A133144/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100308
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Age of Onset
MH  - Asthma/epidemiology/*genetics/*immunology/physiopathology
MH  - Child
MH  - Child, Preschool
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics/metabolism
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics/metabolism
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic
MH  - Retrospective Studies
PMC - PMC7368177
MID - NIHMS1607728
COIS- The study investigators have no conflicts of interest
EDAT- 2010/03/11 06:00
MHDA- 2010/09/15 06:00
PMCR- 2020/07/18
CRDT- 2010/03/11 06:00
PHST- 2010/03/11 06:00 [entrez]
PHST- 2010/03/11 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
PHST- 2020/07/18 00:00 [pmc-release]
AID - 3321 [pii]
AID - 10.2500/aap.2010.31.3321 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2010 Mar-Apr;31(2):120-5. doi: 10.2500/aap.2010.31.3321. 
      Epub 2010 Mar 8.